Correction: RvE1 attenuates polymicrobial sepsis-induced cardiac dysfunction and enhances bacterial clearance

A Correction on
RvE1 attenuates polymicrobial sepsis-induced cardiac dysfunction and enhances bacterial clearance

By Chen J, Purvis GSD, Collotta D, Al Zoubi S, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C (2020). Front. Immunol. 11:2080. doi: 10.3389/fimmu.2020.02080

There was a mistake in Figure 3A as published. The previous image of Figure 3A (MHCII vs. SSC-A scatter plot) was selected from a mouse in the 24-hour post-CLP group that had received RvE1 treatment, as we initially understood that RvE1-treated mice were also subjected to 24-hour CLP. However, to avoid any further confusion, we have now replaced this scatter plot with an image from a mouse subjected to CLP without RvE1 treatment. This change more accurately reflects the legend of Figure 3A: “(A) Flow cytometry gating strategy of mouse peritoneal immune cells 24 h post-CLP”. The corrected Figure 3 and its caption appear below.

Figure 3

Figure 3. RvE1 treatment enhances MHC II- macrophage recruitment in peritoneal cavity. Mice underwent CLP surgery. One hour after CLP, mice were treated with either RvE1 (1 μg/mouse i.v.) or vehicle (100 μl PBS, 0.1% Ethanol). (A) Flow cytometry gating strategy of mouse peritoneal immune cells 24 h post-CLP. (B) Scattergrams illustrating monocyte/macrophage (identified as Ly6G^-CD64⁺) and neutrophil (identified as Ly6G⁺CD64^-) positive events in peritoneal lavages from CLP mice with vehicle or RvE1 treatment. (C, D) Cumulative data for peritoneal CD64⁺ monocytes/macrophages and Ly6G⁺ neutrophils. (E) Scattergrams illustrating macrophage (identified as CD64^highLy6C^low) and monocyte (identified as CD64^lowLy6C^high) positive events in peritoneal lavages from CLP mice with vehicle or RvE1 treatment. (F, G) Cumulative data for peritoneal CD64^highLy6C^low macrophages and CD64^lowLy6C^high monocytes. (H) Scattergrams illustrating MHC II^- macrophage and MHC II⁺ macrophage positive events in peritoneal lavages from CLP mice with vehicle or RvE1 treatment. (I, J) Cumulative data for peritoneal MHC II^- macrophages and MHC II⁺ macrophages. Data are expressed as mean ± SEM of four mice for vehicle group and five mice for RvE1 treatment group. Data were analyzed by unpaired Student’s t-test. *P< 0.05 versus CLP + Vehicle group.

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