- 1INFN Sezione di Torino, Torino, Italy
- 2INFN Sezione di Milano and Università di Milano, Milano, Italy
- 3INFN Sezione di Perugia, Perugia, Italy
- 4INFN Sezione di Bologna, Bologna, Italy
- 5INFN TIFPA and Università di Trento, Trento, Italy
- 6INFN Sezione di Milano and Università dell’Insubria, Varese, Italy
- 7Università degli Studi di Padova, Dipartimento di Fisica e Astronomia and INFN Sezione di Padova, Padova, Italy
- 8INFN Sezione di Padova and Università di Padova, Padova, Italy
- 9INFN Sezione di Pavia and Università di Bergamo, Bergamo, Italy
- 10INFN Sezione di Perugia and Università di Perugia, Perugia, Italy
- 11INFN Sezione di Pavia and Università di Pavia, Pavia, Italy
- 12Università degli Studi di Cassino e del Lazio Meridionale, Dipartimento di Ingegneria Civile e meccanica and INFN Sezione di Padova, Cassino, Italy
Fully depleted CMOS sensors represent a significant step forward in radiation detection, combining the advantages of monolithic active pixel sensors with the enhanced signal collection efficiency of depleted bulk materials. The ARCADIA Collaboration established a technology platform for the development and production of deep sub-micron fully depleted CMOS monolithic sensors with excellent collection efficiency, advancing this semiconductor detector technology with IP cores, ASICs, and back-end dedicated acquisition systems. The sensor technology was demonstrated on system-ready full chip monolithic active pixel sensors with high rate capability and very low power for the detection of charged particles and photons. Innovative CMOS monolithic LGADs featuring a shallow gain layer and implementing a low-gain avalanche diode were developed for time-of-flight detectors, while other prototype ASICs have implemented multi-threshold photon-counting architectures for X-ray imaging. The implementation of fully depleted monolithic strip sensors with embedded electronics and low power density makes the proposed approach a good candidate for future detectors in space applications. The ARCADIA technology will find applications in medical instruments, nuclear imaging and dosimetry, frontier detectors for experimental high energy, and astroparticle physics. This review details the main development achievements by describing the technology demonstrators fabricated and tested and provides a detailed overview of the characteristics and architecture of the ARCADIA-MD3 full-chip monolithic active pixel sensor.
1 Monolithic CMOS pixel detectors
Monolithic complementary metal-oxide semiconductor (CMOS) sensors integrate sensor, readout, and processing electronics in the same silicon substrate. These are fabricated in microelectronics silicon foundries typically focused on CMOS Image Sensor (CIS) technology, with a manufacturing capability in the range of several thousand wafers per week. In the framework of the development of radiation detectors for particle and nuclear physics, CMOS sensors are a very competitive solution compared to traditional hybrid pixel or micro-strip detectors, allowing for significant potential gains in terms of performance, increased robustness, and lower production costs.
In early proposed solutions for the use of a CMOS technology for tracking detectors in high-energy physics (Hillemanns et al., 2013), the signal is collected on a relatively shallow epitaxial layer (typically 15–30
Other approaches embed the electronics in a large collecting electrode, which can be implemented either with a deep nwell or a buried layer, both structures having become standard in modern deep sub-micron processes. The large collection electrode guarantees a uniform electric field across the sensor, allowing for better radiation hardness up to fluences of
An interesting alternative, based on silicon-on-insulator wafers, most commonly uses a buried oxide that separates a thick, high-resistivity sensor layer from a thin, microelectronics-grade layer to create the substrate for the CMOS electronics (Arai et al., 2017). The thickness of the sensing layer can be chosen in a wide range, thus allowing its optimization for the applications of interest. However, the use of SOI wafers entails two critical issues. On the one hand, the high voltage required to deplete the sensors couples through the buried oxide to the thin CMOS substrate, causing a shift of the threshold voltage of the MOSFETs. This problem was addressed by introducing a buried p-well that shields the CMOS layer from the high voltage, although the shape of such a p-well must be carefully optimized to avoid performance degradation due to the increase of the sensor capacitance. On the other hand, SOI-based sensors are prone to accumulate charge in the buried oxide layer after irradiation, which can degrade the performance of the CMOS circuitry. This is typically solved by using a second buried oxide layer for which the inner silicon layer, encapsulated between the two oxides and biased with a dedicated voltage domain, counteracts the effect of the accumulated charge. This layered implementation significantly increases the cost of the substrate procurement and wafer processing of this highly specialized technology.
Fully depleted CMOS sensors, featuring a completely depleted substrate with a thickness of several hundred micrometers, with the charge collected exclusively by drift, offer the possibility of replacing conventional hybrid pixels and strips in most applications. This possibility is hence relevant for experiments employing silicon detectors on future particle colliders and astroparticle physics experiments in space, with a potential application also in the medical field. The technology proposed in this study allows for the implementation of silicon sensors with an active thickness of up to 500
2 The ARCADIA CMOS sensor technology
The SEED and ARCADIA projects, funded by the INFN CSN5, established a collaboration with the silicon foundry LFoundry s.r.l. to create an INFN platform to develop and produce high-efficiency deep-submicron CMOS monolithic sensors. These are implemented on n-type high-resistivity
Figure 1A illustrates the cross-section of a pixel array chip with a backside bias electrode on a heavily doped bias layer, forming the backside junction. The depletion layer hence develops from the backside of the n-type substrate when a negative bias voltage is applied to the p+ electrode. The choice of using the backside junction to bias the sensor allows for a full depletion of the substrate without the need to apply high voltage potentials at the front side, thus enabling the use of low-voltage CMOS electronics to read out the fast signals produced by electron drift current. The backside is processed after thinning to the final thickness and implanting a very shallow p+ boron-doped region subsequently activated with a laser annealing; Figure 1B illustrates a sensor thinned down to 200

Figure 1. Detailed cross-section of the ARCADIA fully depleted CMOS sensor technology, depicting the arrangement of the pixel array and guard-ring terminations on the back-side (A). Embodiments of the technology for thicker sensors with backside lithography (B), for thinner sensors with maskless backside using a p+ implantation (C), and a maskless option (C) using a p+ starting substrate as a passive carrier (D).
3 ARCADIA prototypes and full-chip demonstrators
Involving seven INFN divisions and over 50 researchers and engineers, the ARCADIA1 initiative advanced semiconductor sensor technology while also developing IP cores, ASICs, and dedicated data acquisition systems. This collaboration demonstrated the scalability and technology readiness of the proposed MAPS sensor through the development of a full-size system-ready demonstrator featuring a low-power, high-density pixel matrix CMOS monolithic sensor. Other deliverables of the project include passive pixel and strip test structures for sensor characterization, monolithic silicon strip arrays with embedded readout electronics and silicon strip readout ASICs, test vehicles for multi-threshold photon counting architectures, small-scale prototypes for ultra-low power and fast timing, and mixed-signal ASICs for fast timing with sensors implementing a gain layer. The circuits and sensors were produced through a series of single-project wafer engineering runs employing different splits of starting substrate, process options, and final wafer thicknesses. The list of designs on board the ARCADIA engineering runs and its correspondence to the reticle floorplan (Figure 2) is depicted below.

Figure 2. Reticle floorplans for the ARCADIA engineering runs, mask sets for the first (A) and second (B) single-project wafer productions.
3.1 ARCADIA-MD3 FD-MAPS main demonstrator (512 × 512 pixels)
The system-ready fully depleted monolithic active pixel sensor has an active area of
3.2 ARCADIA-miniD FD-MAPS mini demonstrator (512 × 32 pixels)
Smaller FD-MAPS demonstrators for testability and debugging implemented power management IPs (Bianco, 2021; Traversi et al., 2023) and configurability options for yield optimization on large sensors, using a dedicated low drop-out LDO regulator for each section of the chip.
3.3 FD-MAPS and test structures for timing applications
Third-party designs from the Paul Scherrer Institute PSI and ETH Zurich for timing applications. Details on the design characteristics and silicon results of MoTiC (Monolithic Pixel Detector with Timing) can be found in Burkhalter et al. (2024).
3.4 MATISSE low power front-end
MATISSE-LP is a small-scale FD-MAPS prototype featuring a 2 × 2
3.5 Passive pixel and strip test structures
Arrays of passive pixels with parallel connections used for electrical characterisation (I-V and C-V curves with probe station) were used, with studies of charge collection efficiency and tests with pulsed IR and NIR lasers. Both pixel and matrix test structures implement pitches ranging from 50 down to 10
3.6 ASTRA 64-channel mixed signal ASIC for Si-Strip readout
A mixed-signal silicon strip readout ASIC for space-borne experiments with very low-power performance (
3.7 ASTRA-VI 32-channel monolithic strip and fully functional readout electronics
A proof-of-concept CMOS monolithic strip block featured fully functional readout electronics. The 32-block of
3.8 HERMES small-scale demonstrator for fast timing
The HERMES Discrete-time Electronics CMOS Sensor is a first prototype for timing applications, targeting a sub-ns time resolution without the use of a gain layer. Each of the 48 50-
3.9 MADPix multi-pixel active demonstrator chip for fast timing
The use of a p-type gain implant beneath the n+ collecting electrode to push the timing performance was tested both with passive pixel and strip test structures and with a first 4.4 × 16.4
3.10 METPC multi-energy thresholds photon counting chip
The first small-scale demonstrator of an X-ray multi-photon counter using the ARCADIA technology platform is a fully digital 896-pixel demonstrator (8 × 112 pixels) with a pitch of 110
3.11 COBRA first prototype of an active CMOS pad detector for tracking and dosimetry
The COBRA chip is a small area pad detector O (
4 The ARCADIA-MD3 fully depleted MAPS
ARCADIA-MD3 is a system-ready versatile full-chip demonstrator for the FD-MAPS embodiment of the LF11is CMOS monolithic sensor technology developed by the collaboration. The sensor active region consists of 512 × 512 pixels, each pixel embedding the collection electrode, analog and digital circuitry on a 25
The ARCADIA-MD3 chip physical and logical hierarchy organization is shown in Figure 4. The active sensor matrix (512 × 512) is partitioned into sections (32 × 512) which are independently read out and have a dedicated serializer and c-LVDS data link. The sections are in turn composed of 16 core columns (2 × 512) arranged as double-pixel columns with mirrored analog and digital domains. Each of these core columns stacks 16 cores (2 × 32), which are the minimum synthesisable unit in the matrix and implement a buffering scheme in such a way that the propagation delay of hit and handshaking signals is optimized. The cores are then subdivided into 2 × 2 pixel regions to allow the sharing of logical resources such as pixel addressing (addresses are hard-coded in the region), data multiplexing and bus arbitration logic.
The data-driven binary readout is based on a priority-encoding solution, with the hitmap region (hardcoded during synthesis) and core (generated during readout) addresses being propagated to the section readout unit whenever the pixel receives the writing token. For each event, the chip buffers the pixel hit into a status bit, which is then cleared on readout. In order to minimize the latency to clear the pixel, a clustering readout is used to group the payload of multiple hits on each transaction. For the implementation of the clustering readout, the matrix is configured into primary and secondary pixel regions, the former having readout capability. Therefore, the primary’s data packets to be sent to the periphery are composed of the hitmap of the primary itself, the hitmap of one of the neighboring secondary pixel regions, and a bit indicating whether the secondary is a top or bottom neighbor. The hitmap is hence the collection of the status of the pixels—for example, if all the pixels in the secondary are hit, its hitmap will be 1,111; if otherwise, only the top ones are hit, and the hitmap will be 1,100. Each pixel has an associated status register (FF), and for each hit, the pixel front-end amplifier generates a discriminator output high which is buffered and sets the status register to 1. The full flag of each primary pixel region in the column is OR-ed with the one of the preceding (top) ones, creating a token chain. As soon as the token signal is propagated to the periphery section readout unit (Figure 5), the timestamp is latched for the column. A selector Finite-State Machine (FSM) selects a column to drain, samples its data, and sends a read signal upward. The selector FSM can read from a column for a maximum programmable number of times. When the maximum is reached or the token goes down from the column, the the selector addresses the next one with the token signal active. The payload consisting of the column data, column adddress and timestamp is then sent to the output FIFO and will be sampled by the periphery circuits.
This low-power asynchronous architecture implements a readout logic where the system clock is not propagated to the pixel matrix. The clock is generated off-chip in a range of 100–320 MHz and is used by the double data rate (DDR) serializers and data transceivers, implemented with a custom high data rate and low-power data link (Pezzoli et al., 2021). The 32-bit data words are 8b10b encoded into 40-bit packets and, if the FIFO of the section readout unit is empty, synchronization packets are transmitted for keeping the clock aligned with the DAQ.
The periphery circuitry, FIFOs and readout units are designed such that a 100 MHz/cm2 particle hit rate can be handled and transmitted using 16 DDR output links. For very low power applications, the rate capability of the sensor is scaled down, and all data produced by the matrix is buffered from all section readout units into a central FIFO. The clock gating turns off the finite-state machines, encoders and serializers from all output links except one, and all but one of the c-LVDS data transceivers are disabled. Hence, the ARCADIA-MD3 chip can be configured to operate in a high or low rate mode (Figure 6). The power density of the full chip in low rate mode is approximately 10 mW/cm2. Depending on the driving strength settings for the c-LVDS links, which can be configured with 3-bit global configuration registers, the total power density of the chip operating in high rate mode is 17–30 mW/cm2.
The ARCADIA-MD3 FDMAPS, which is seen mounted on a front-end carrier board in Figure 7, was extensively tested using radioactive sources and in cosmic ray stands. A detailed description of the analog and digital circuits and electrical characterisation of the CMOS sensor and the results of a test beam characterisation with a three-plane telescope using the 120 GeV proton beam at FNAL will be discussed in detail in forthcoming publications in preparation.

Figure 7. ARCADIA-MD3 FD-MAPS mounted on a PCB. Image of a leaf obtained with an X-ray radioactive source (55Fe) and a
5 Conclusion
The ARCADIA collaboration developed a technology platform for the design and production of fully depleted CMOS monolithic sensors using a proprietary INFN-LFoundry sensor technology. This development, financed by an INFN CSN5 Open Call, allowed for the design and production of the ARCADIA-MD3 system-grade 515 × 512 FD-MAPS demonstrator with a very low power consumption, monolithic CMOS silicon strip arrays with embedded electronics, prototype chips for X-ray imaging and medical applications, and the implementation of a CMOS LGAD sensor concept for future timing detectors. The possibility to fully deplete very thick high-resistive silicon substrates paves the way for the use of these sensors in future medical instruments for proton, X-ray, molecular, and nuclear imaging, while the unprecedented power density of
Author contributions
MD: Writing – original draft. AA: Writing – review and editing. GA: Writing – review and editing. FA: Writing – review and editing. GB: Writing – review and editing. G-FD: Writing – review and editing. ToC: Writing – review and editing. MC: Writing – review and editing. DC: Writing – review and editing. ThC: Writing – review and editing. SD: Writing – review and editing. DF: Writing – review and editing. AG: Writing – review and editing. PG: Writing – review and editing. SG: Writing – review and editing. RI: Writing – review and editing. MM: Writing – review and editing. SM: Writing – review and editing. CN: Writing – review and editing. LP: Writing – review and editing. DP: Writing – review and editing. AP: Writing – review and editing. MP: Writing – review and editing. PP: Writing – review and editing. LR: Writing – review and editing. ER: Writing – review and editing, Investigation. AR: Writing – review and editing. RS: Writing – review and editing. GT: Writing – review and editing. JW: Writing – review and editing.
Funding
The author(s) declare that financial support was received for the research and/or publication of this article. This work has received funding from INFN CSN5 under the Call 2018 project ARCADIA.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision.
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Footnotes
1ARCADIA Advanced Readout CMOS Architectures with Depleted Integrated sensor Arrays.
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Keywords: CMOS, fully depleted monolithic sensor, ASIC, low-power architectures, semiconductor sensors, integrated circuits, VLSI
Citation: Da Rocha Rolo M, Andreazza A, Ambrosi G, Alfonsi F, Balbi G, Dalla Betta G-F, Croci T, Caccia M, Chiappara D, Corradino T, Durando S, Falchieri D, Gabrielli A, Giubilato P, Garbolino S, Iuppa R, Mandurrino M, Mattiazzo S, Neubüser C, Pancheri L, Pantano D, Paterno A, Pezzoli M, Placidi P, Ratti L, Ricci E, Rivetti A, Santoro R, Traversi G and Wyss J (2025) ARCADIA fully depleted CMOS MAPS development with LFoundry 110 nm CIS. Front. Sens. 6:1603755. doi: 10.3389/fsens.2025.1603755
Received: 31 March 2025; Accepted: 03 July 2025;
Published: 11 August 2025.
Edited by:
Omid Kavehei, The University of Sydney, AustraliaReviewed by:
Soumyajit Mandal, Brookhaven National Laboratory (DOE), United StatesMassimo Minuti, Universities and Research, Italy
Copyright © 2025 Da Rocha Rolo, Andreazza, Ambrosi, Alfonsi, Balbi, Dalla Betta, Croci, Caccia, Chiappara, Corradino, Durando, Falchieri, Gabrielli, Giubilato, Garbolino, Iuppa, Mandurrino, Mattiazzo, Neubüser, Pancheri, Pantano, Paterno, Pezzoli, Placidi, Ratti, Ricci, Rivetti, Santoro, Traversi and Wyss. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Manuel Da Rocha Rolo, ZGFyb2NoYXJAdG8uaW5mbi5pdA==
†Present address: Thomas Corradino, Fondazione Bruno Kessler (FBK), Trento, Italy