Abstract
In the pituitary sella, the coexistence of pituitary adenoma and primary pituitary lymphoma is exceedingly rare. Thus far, only six cases have been reported. Here, we present the seventh case of coexisting pituitary adenoma and primary pituitary lymphoma, which was difficult to differentiate from other sellar tumors. To our knowledge, this is the first case of the prolactin subtype of the pituitary adenoma in literature. We have also systematically reviewed the literature and summarized the characteristics of coexisting pituitary adenoma and lymphoma. We believe this report provides a new clinical reference for the diagnosis and treatment of collision tumors of pituitary adenoma and lymphoma.
Introduction
Collision tumor in the sellar region is a rare condition; it refers to two coexisting tumors of different shapes attached to each other. Typically, a collision tumor in the sellar region is characterized by the coexistence of pituitary adenoma and another tumor. Reportedly, the pituitary adenoma can be associated with meningioma (), Rathke's cleft cyst (), craniopharyngioma (), gangliocytoma (), and other neoplasms. Among them, the coexistence of pituitary adenoma and primary pituitary lymphoma is extremely rare. It is difficult to distinguish it from other sellar region tumors, and the perioperative diagnosis is difficult because the clinical and radiological manifestations of most cases are similar to pituitary adenomas. Only six cases of pituitary adenoma associated with lymphoma have, thus far, been reported. Here, we report the seventh case and systematically review the literature.
Case Presentation
In May 2020, a 41-year-old Asian male was hospitalized with a history of intermittent stabbing headache, without progressive deterioration of visual acuity or visual field. Table 1 presents the results of the endocrine examination. Brain CT showed a tumor with calcification in the sellar region (Figure 1A). The brain MRI showed that the sellar floor was eroded; further, the pituitary stalk was not clear. The tumor showed hypointensity in both T1-weighted and T2-weighted MRI images. A contrast-enhanced MRI showed a significant enhancement of under-homogeneity (Figures 1B–E). These radiological manifestations indicated that the sellar mass was pituitary adenoma.
Table 1
| Hormone | Level measured | Normal levels |
|---|---|---|
| GH | 0.51 ng/ml | 0.014-5.219 ng/ml |
| PRL | 11 ng/ml | 3.7-17.9 ng/ml |
| ACTH | 94.05 pg/ml | 10.1-57.6 pg/ml |
| TSH | 6.84 mIU/L | 0.465-4.680 mIU/L |
Endocrine examination results.
Bold text indicates abnormal data.
GH, growth hormone; PRL, prolactin, ACTH, adrenocorticotropic hormone; TSH, thyroid-stimulating hormone.
Figure 1
The patient underwent endoscopic endonasal transsphenoidal tumor resection. A tough tumor was encountered in the sphenoid sinus and sellar region. The tumor was abnormally hypervascular, and there was bone inside the tumor. The volume of intraoperative bleeding was about 200 mL. By the end of the surgery, all the tumors were removed in pieces. Postoperatively, the patient recovered well. The symptoms of headache were significantly relieved. Pathological results showed sparsely granulated lactotroph adenoma combined with primary pituitary diffuse large B-cell lymphoma (Figure 1F). The immunohistochemistry results are shown in Table 2.
Table 2
| Biomarker | Result |
|---|---|
| CD45, CD20, CD79α, CD10, Bcl-6, c-MYC, MUM1, Pit-1, PRL, Syn, CK18 | Positive (+) |
| Bcl-2, SF-1, T-Pit, GH, TSH, FSH, LH, ACTH | Negative [-] |
Immunohistochemistry results.
A postoperative head MRI showed that there was no residual tumor in the sellar region. A PET-CT scan did not show increased uptake in the pituitary gland and other parts. The results of bone marrow puncture showed that the degree of proliferation was V/VII, G:E = 2.3:1, and nuclear heterogeneous cells were occasionally seen. Then, he received four cycles of chemotherapy. The R-MI protocol (rituximab+methotrexate+ifosfamide) was used, accompanied by supportive treatment.
The patient underwent follow-up examinations at postoperative 6 months and 1 year. The patient was generally in good condition, and the tumor did not recur. A series of brain MRIs showed no evidence of tumor regrowth (Figures 1G–J). The patient will continue to be followed up.
Discussion
Collision tumors of pituitary adenoma and primary pituitary lymphoma in the sellar region are extremely rare. We systematically reviewed the literature to identify the characteristics of coexisting pituitary adenoma and lymphoma. To our knowledge, thus far, only seven cases have been reported, including this case. We have summarized the characteristics of these seven cases (–) and presented them in Table 3.
Table 3
| Case report | Age/Sex | Symptoms | Treatment | Subtype of PA | Subtype of PL | Recurrence |
|---|---|---|---|---|---|---|
| Kuhn. () | 67/F | VD, VFD | ST | FSH | T-LBL | Yes (6 Mo) |
| Au. () | 82/M | HA, VD, VFD | BIOP, RT | TSH | DLBCL | ND |
| Romeike. () | 64/F | HA, VFD | ST, MT, RT | FSH | T-LBL | No (19 Mo) |
| Martinez. () | 71/F | VFD | ST, RT | GH | DLBCL | No (12 Mo) |
| Ban. () | 74/M | HA | ST, MT | FSH | DLBCL | No (32 Mo) |
| Gupta. () | 55/F | HA, VD | ST | ACTH | T-LBL | ND |
| Present case | 41/M | HA | ST, MT | PRL | DLBCL | No (12 Mo) |
Summary cases of coexistence of pituitary adenoma and pituitary lymphoma.
PA, pituitary adenoma; PL, pituitary lymphoma; F, female; M, male; VD, visual deterioration; VFD, visual field defect; HA, headache; ST, surgical treatment; BIOP, biopsy; RT, radiation therapy; MT, medical treatment; FSH, follicle-stimulating hormone; TSH, thyroid-stimulating hormone; GH, growth hormone; PRL, prolactin; T-LBL, T-cell lymphoblastic lymphoma; DLBCL, diffuse large B-cell lymphoma; Mo, month; ND, not described.
The pathophysiological mechanism of tumorigenesis remains unclear, as there are only a very small number of cases currently reported. The local immune changes in the pituitary gland may be brought about by tumorigenesis. It is reported that primary pituitary lymphoma can develop in immunosuppressed individuals (). At the same time, the occurrence and development of pituitary adenomas are closely related to immune infiltration (). Whether immune-related mechanisms are involved in the occurrence of collision tumors is still poorly understood and needs to be investigated in more patients.
The coexistence of pituitary adenoma and primary pituitary lymphoma has no special clinical manifestations. The most common clinical manifestation is headache; it was noted in 5 of 7 cases (Table 3). Whether the patient's vision and visual field are affected mainly depends on the size of the tumor. Eyesight decline or visual field defect in patients occurred in five cases, but not in the present report (Table 3). Imaging findings are similar to pituitary adenomas, which makes preoperative diagnosis very challenging (Figure 1). Pathology is the gold standard for diagnosis. The diagnosis of collision tumor of pituitary adenoma and primary pituitary lymphoma in all seven cases was confirmed by pathology. The subtypes of pituitary adenoma can be follicle-stimulating hormone (FSH), Thyroid-stimulating hormone (TSH), Growth hormone (GH), Adrenocorticotropic hormone (ACTH), or Prolactin (PRL). The FSH subtype of pituitary adenoma is the most common (Table 3). This case report was the first to suggest the PRL subtype of pituitary adenoma. The subtypes of pituitary lymphoma are also not consistent. It can be T-cell lymphoblastic lymphoma (T-LBL) or diffuse large B-cell lymphoma (DLBCL). It is different from primary pituitary lymphoma. The most common subtypes of primary pituitary lymphoma are B-cell lymphoma, followed by T cell and NK/T cell types ().
Surgical management is the most important treatment option for collision tumors of pituitary adenoma and primary pituitary lymphoma. The patients in the six previous cases underwent surgical treatment. In Au et al.'s () case report, the patient was an 82-year-old man. Perhaps because of advanced age, the patient did not undergo surgical resection after tumor biopsy but underwent radiotherapy. With the development of neuroendoscopic technology, endoscopic transnasal resection of collision tumors in the sellar region has become the treatment of choice. In our case, the patient underwent endoscopic endonasal transsphenoidal tumor resection. In the end, all the tumors were removed in pieces. If the tumor is completely resected and there is no evidence of systemic lymphoma, no additional radiotherapy is required. However, DLBCL is a highly malignant lesion. To prevent tumor recurrence, chemotherapy can be used appropriately. If the tumor remains or there is evidence of systemic lymphoma, additional radiotherapy or chemotherapy is required. Chemotherapy was used in three cases (Table 3). The classic chemotherapy drug is methotrexate. The external beam radiation of the head was used in three cases (–). In the case report by Romeike et al. (), we found that radiotherapy and chemotherapy were used after the subtotal removal of the lesion. A thorough postoperative examination, including brain MRI, PET-CT, bone marrow aspirate, and bone marrow trephine biopsy, are necessary to reveal any sign of systemic manifestation of the lymphoma spread.
The recurrence rate after total resection is low, but there is still recurrence. In the case report by Kuhn et al. published in 1999 (), the tumor recurred 6 months after the operation. Perhaps, the available surgical technology then was not optimal, failing to completely remove the tumor in the first operation. Moreover, the patient did not receive chemotherapy and radiotherapy after the first operation. The patient, therefore, had to undergo a second operation. The control of collision tumors is more difficult than simple pituitary adenoma, so the follow-up cycle needs to be prolonged. We suggest that the follow-up should be extended to more than 3 years after the initial operation. If the tumor relapses, a reoperation is still the first choice, but radiotherapy and chemotherapy need to be considered after the operation.
Conclusions
The coexistence of pituitary adenoma and primary pituitary lymphoma in the sellar region is extremely rare. The disease diagnosis, tumor control, and overall survival are more challenging to achieve for collision tumors than for pituitary adenomas alone. The gross total resection of both tumors is very important for satisfactory tumor control. The follow-up assessment of patients should be appropriately prolonged.
Limitation
Because the patient's preoperative diagnosis was a conventional pituitary adenoma, video recording was not performed during the operation. Therefore, there are no intraoperative images. Furthermore, the report lacks neuro-ophthalmological examination, because the patient claimed to have normal visual acuity and field. Lastly, only 1-year postoperative follow-up was performed on the patient. We plan to continue to monitor the situation of this patient.
Funding
This work was supported by grants from the Taishan Scholar Project of Shandong Province of China (tsqn202103200) and the National Natural Science Foundation of China (81701159).
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Statements
Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics statement
Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Author contributions
ML conceived the study and edited the final manuscript. SR and QL collected the clinical data and performed a literature review. YZ confirmed the pathological analysis. BL reviewed the clinical notes and produced the draft manuscript. YX and LZ conceived the research and helped with the writing of the manuscript. All authors read and approved the final manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- CT
Computed tomography
- MRI
Magnetic resonance imaging
- FSH
Follicle-stimulating hormone
- TSH
Thyroid-stimulating hormone
- GH
Growth hormone
- PRL
Prolactin
- T-LBL
T-cell lymphoblastic lymphoma
- DLBCL
Diffuse large B-cell lymphoma
- PET
Positron emission tomography.
Abbreviations
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Summary
Keywords
collision tumor, pituitary adenoma (PA), pituitary lymphoma, DLBCL - diffuse large B cell lymphoma, review
Citation
Ren S, Lu Q, Xiao Y, Zhang Y, Zhang L, Li B and Li M (2022) Coexistence of Pituitary Adenoma and Primary Pituitary Lymphoma: A Case Report and Review of the Literature. Front. Surg. 9:842830. doi: 10.3389/fsurg.2022.842830
Received
24 December 2021
Accepted
16 February 2022
Published
16 March 2022
Volume
9 - 2022
Edited by
Philipp Taussky, The University of Utah, United States
Reviewed by
Nguyen Minh Duc, Pham Ngoc Thach University of Medicine, Vietnam; Selfy Oswari, Indonesia National Brain Center / Universitas Padjadjaran, Indonesia
Updates
Copyright
© 2022 Ren, Lu, Xiao, Zhang, Zhang, Li and Li.
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*Correspondence: Mengyou Li limengyou@163.com
†These authors have contributed equally to this work and share first authorship
This article was submitted to Neurosurgery, a section of the journal Frontiers in Surgery
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.