ORIGINAL RESEARCH article
Front. Surg.
Sec. Cardiovascular Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1561690
This article is part of the Research TopicState of the Art in Antithrombotic TherapyView all 6 articles
Evaluation of the SAMe-TT 2 R 2 score to predict the quality of anticoagulation control in patients after mitral valve replacement
Provisionally accepted
- 1Department of Cardiology Surgery, Xinxiang Central Hospital, Xinxiang, China
- 2Zhongshan Medical College ,Sun Yat sen University, Guangzhou, China
- 3Dalian Municipal Central Hospital, Dalian, Liaoning Province, China
- 4Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
This study aimed to evaluate the role of the SAMe-TT2R2 score in the prediction of anticoagulation control after mechanical mitral valve replacement.： We retrospectively reviewed clinical data of 160 patients who received mechanical mitral valve replacement at Beijing Anzhen Hospital from January to December 2013. Collected data included the patient's general information and any history of medication, smoking, post-operative embolism due to anticoagulant, bleeding complications, and death information.In the SAMe-TT2R2 score results, the lowest score was 2 points (5.6%), and the highest score was 7 points (0.6%). The number of people with 4 points was the largest (69 people, 43.1%). When the cut-off value of the SAMe-TT2R2 score was set to ≥4, the sensitivity and specificity of predicting Time in Therapeutic Range (TTR)≥65% were 69.8% and 93.1%, respectively. The Youden index was 0.629. If the cut-off value of the SAMe-TT2R2 score was set to ≤4, the sensitivity and specificity of predicting TTR≥65% were 93.0% and 44.1%, respectively, and the Youden index was 0.371.无下划线 设置格式[小叶]: 无下划线 设置格式[小叶]: 无下划线 设置格式[小叶]: 无下划线 设置格式[小叶]:power of the SAMe-TT2R2 score for TTR≥65%. The figure showed that when the cut-off point was ≥4, the best combination of sensitivity and specificity was shown (69.8% and 93.1%, respectively). The Area Under the Curve (AUC) was 0.854.After mechanical mitral valve replacement, the SAME-TT2R2 model can effectively predict the TTR level during the course of oral warfarin anticoagulation therapy. The SAMe-TT2R2 score ≥4 can predict TTR<65%.
Keywords: SAMe-TT2R2 score, Anticoagulation control, Time in therapeutic range, Mitral valve replacement, TTR
Received: 16 Jan 2025; Accepted: 23 May 2025.
Copyright: © 2025 Shubin, Yilin, Yang, Qiuming and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: LI Shubin, Department of Cardiology Surgery, Xinxiang Central Hospital, Xinxiang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.