ORIGINAL RESEARCH article
Front. Surg.
Sec. Thoracic Surgery
Effects of preoperative nutritional support combined with esketamine on recovery and analgesia after thoracoscopic radical resection of lung cancer in elderly patients
Provisionally accepted
Yu Hou1
Zhiru Zhan2*- 1The First Hospital of Shanxi Medical University, Taiyuan, China
- 2Zhongshan Hospital affiliated to Xiamen University, Xiamen, China
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Aim: To explore the effects of preoperative nutritional support combined with esketamine on recovery and postoperative pain management in elderly patients undergoing thoracoscopic radical resection for lung cancer. Methods: A total of 165 elderly patients with lung cancer who underwent thoracoscopic radical resection at our hospital between June 2021 and March 2023 were enrolled and divided into a study group (SG, n=85) and a control group (CG, n=80). The SG received patient-controlled analgesia with esketamine, sufentanil, dexamethasone, and dexmedetomidine, while the CG received sufentanil, dexamethasone, and dexmedetomidine. The SG received nutritional support both pre-and postoperatively, whereas the CG received it only postoperatively. We compared resting and coughing Visual Analog Scale (VAS) scores, Ramsay sedation scores at 6, 12, 24, and 48 h post-surgery, the number of analgesic pump compressions and drug consumption within 48 h, adverse reactions, recovery indicators, immune function, nutritional status, and quality of life between the groups. Results: Compared to the CG, the SG demonstrated significantly lower VAS scores at rest and during cough, along with higher Ramsay sedation scores at 6, 12, 24, and 48 h postoperatively (P < 0.05). The SG also required fewer analgesic pump compressions and lower analgesic drug dosages within 48 h (P < 0.05). The incidence of adverse reactions within 48 h was lower in the SG (P < 0.05). Postoperative recovery indicators, including time to first exhaust, first defecation, and hospitalization, were significantly shorter in the SG (P < 0.05). Furthermore, the SG showed significantly elevated levels of Immunoglobulin G (IgG), IgM, IgA, albumin (Alb), transferrin (TRF), and prealbumin (PAB) (P < 0.05), as well as higher scores across all 36-Item Short Form Health Survey (SF-36) dimensions (P < 0.05). Conclusion: Preoperative nutritional support combined with esketamine was associated with reduced pain, improved postoperative recovery indicators, better maintained immune function and nutritional status, and a higher quality of life in elderly patients after thoracoscopic radical resection of lung cancer.
Keywords: lung cancer, Thoracoscopic radical resection, preoperative nutritionalsupport, Esketamine, Analgesia, Immune function
Received: 12 Aug 2025; Accepted: 01 Dec 2025.
Copyright: © 2025 Hou and Zhan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiru Zhan
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