ORIGINAL RESEARCH article
Front. Surg.
Sec. Orthopedic Surgery
Risk Factors for Subsequent Vertebral Fracture after Percutaneous Vertebroplasty in Patients with Osteoporotic Vertebral Compression Fractures in Northern China
Yafeng Guo 1
Yaheng Zhao 1
Qi Sun 1
Hongyang Gao 1
Wei Zhang 2
1. The First hospital of Hebei Medical University, Shijiazhuang, China
2. The Third Hospital of Hebei Medical University, Shijiazhuang, China
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Abstract
Background: Osteoporotic vertebral compression fractures (OVCF) are commonly treated with percutaneous vertebroplasty (PVP). However, Subsequent vertebral fracture (SVF) following PVP surgery, as a serious complication, has attracted widespread attention. The purpose of this study was to investigate the risk factors for SVF after PVP in elderly patients with OVCF. Methods: This study retrospectively analyzed elderly patients who underwent PVP for single-level OVCF. Patients were divided into the SVF group and the control group. Demographic, surgery-related, and imaging parameters were collected. Independent risk factors were identified through univariate and multivariate logistic regression analyses. Results: A total of 162 elderly patients over 60 years old with single-level OVCF treated by PVP were included in this study, among whom 27 patients developed SVF. Logistic regression analysis revealed that low body mass index (BMI) (OR = 0.608; 95% CI = 0.426-0.867, P = 0.006), intradiscal cement leakage (OR = 10.993; 95% CI = 2.391-50.540, P = 0.002), and low Hounsfield unit (HU) values (OR = 0.958; 95% CI = 0.923-0.995, P = 0.025) were significantly associated with SVF after PVP for the treatment of OVCF and were identified as independent risk factors. Conclusion: Low BMI, intradiscal cement leakage, and low HU values were independent risk factors for SVF after PVP surgery for the treatment of OVCF.
Summary
Keywords
Osteoporosis, Osteoporotic vertebral compression fracture, Percutaneous vertebroplasty, risk factor, subsequentvertebral fracture
Received
13 January 2026
Accepted
20 February 2026
Copyright
© 2026 Guo, Zhao, Sun, Gao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wei Zhang
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