Frontiers in Systems Biology

Original Research

Published on 03 Apr 2024

Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy

in Translational Systems Biology and In Silico Trials

Quim Martí-Baena
Andreu Pascuet-Fontanet
Tomas Berjaga-Buisan
Miriam Caravaca-Rodríguez
Jaume Puig-Costa-Jussà
Avencia Sanchez-Mejias
Dimitrije Ivančić
Sira Mogas-Díez
Marc Güell
Javier Macia

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1270071

2,210 views

Perspective

Published on 03 Apr 2024

Is there room in epilepsy for the claustrum?

in Integrative Systems Neuroscience

Glenn D. R. Watson
Stefano Meletti
Anil K. Mahavadi
Pierre Besson
S. Kathleen Bandt
Jared B. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1385112

1,638 views

Original Research

Published on 27 Mar 2024

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

in Data and Model Integration

Rayna M. Nolen
Lene H. Petersen
Karl Kaiser
Antonietta Quigg
David Hala

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1367562

1,207 views
1 citation

Original Research

Published on 25 Mar 2024

Mathematical modeling of temperature-induced circadian rhythms

in Translational Systems Biology and In Silico Trials

Lingjun Lu
Yannuo Li
Rene Schloss
Ioannis P. Androulakis

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1256398

1,585 views
1 citation

Methods

Published on 21 Mar 2024

A robust ensemble feature selection approach to prioritize genes associated with survival outcome in high-dimensional gene expression data

in Integrative Genetics and Genomics

Phi Le
Xingyue Gong
Leah Ung
Hai Yang
Bridget P. Keenan
Li Zhang
Tao He

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1355595

1,298 views
1 citation

Original Research

Published on 15 Mar 2024

Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IP3 production and degradation

in Multiscale Mechanistic Modeling

Clara Octors
Ryan E. Yoast
Scott M. Emrich
Mohamed Trebak
James Sneyd

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1343006

1,491 views
1 citation

Mini Review

Published on 13 Mar 2024

Computational insights in cell physiology

in Data and Model Integration

Geneviève Dupont
Didier Gonze

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1335885

951 views

Original Research

Published on 08 Mar 2024

Uncertainty quantified discovery of chemical reaction systems via Bayesian scientific machine learning

in Translational Systems Biology and In Silico Trials

Emily Nieves
Raj Dandekar
Chris Rackauckas

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1338518

4,077 views
4 citations

Perspective

Published on 08 Mar 2024

Advancing precision medicine therapeutics for Parkinson’s utilizing a shared quantitative systems pharmacology model and framework

in Translational Systems Biology and In Silico Trials

Christopher Denaro
Diane Stephenson
Martijn L. T. M. Müller
Benedetto Piccoli
Karim Azer

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1351555

2,505 views
3 citations

Perspective

Published on 08 Mar 2024

Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity

in Data and Model Integration

Patrick C. Kinnunen
Kenneth K. Y. Ho
Siddhartha Srivastava
Chengyang Huang
Wanggang Shen
Krishna Garikipati
Gary D. Luker
Nikola Banovic
Xun Huan
Jennifer J. Linderman

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1333760

1,658 views
1 citation

Specialty Grand Challenge

Published on 06 Mar 2024

Expanding our thought horizons in systems biology and medicine

in Systems Concepts, Theory and Policy in Biology and Medicine

Jennifer C. Lovejoy

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1385458

1,376 views
2 citations

Original Research

Published on 01 Mar 2024

Assessing electrogenetic activation via a network model of biological signal propagation

in Integrative Systems Microbiology

Kayla Chun
Eric VanArsdale
Elebeoba May
Gregory F. Payne
William E. Bentley

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1291293

1,629 views
2 citations

Original Research

Published on 01 Mar 2024

Pareto task inference analysis reveals cellular trade-offs in diffuse large B-Cell lymphoma transcriptomic data

in Translational Systems Biology and In Silico Trials

Jonatan Blais
Julie Jeukens

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1346076

1,247 views

Perspective

Published on 27 Feb 2024

BioModels’ Model of the Year 2023

in Data and Model Integration

Rahuman S. Malik Sheriff
Hiroki Asari
Henning Hermjakob
Wolfgang Huber
Thomas Quail
Silvia D. M. Santos
Amber M. Smith
Virginie Uhlmann

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1363884

2,381 views

Original Research

Published on 15 Feb 2024

Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation

in Data and Model Integration

Ashti M. Shah
Ruben Zamora
Derek Barclay
Jinling Yin
Fayten El-Dehaibi
Meghan Addorisio
Tea Tsaava
Aisling Tynan
Kevin Tracey
Sangeeta S. Chavan

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1266279

1,125 views
2 citations

Editorial

Published on 02 Feb 2024

Editorial: Combining mechanistic modeling with machine learning to study multiscale biological processes

in Multiscale Mechanistic Modeling

Shayn Peirce-Cottler
Yoram Vodovotz

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1367549

1,082 views