In the original article, there was a mistake in the legend for Tables 2 and 4 as published. In these tables, the number of cows in each group were stated incorrectly. The correct legend appears below.
Table 4
| IV | Mid-lactation | Post-partum | P-value |
|---|---|---|---|
| Cmax (μg/mL) | 1.22 (0.92–1.55) | 1.06 (0.84–1.34) | 0.26 |
| Tmax (h) | 0.13 (0.08–0.19) | 0.23 (0.08–4.01) | 0.73 |
| Vd (L/kg) | 0.29 (0.24–0.35) | 0.31 (0.19–0.48) | 0.94 |
| CL (L/kg/h) | 0.03 (0.02–0.03) | 0.01 (0.009–0.02) | 0.009 |
| AUC∞ (h x μg/mL) | 8.26 (6.62–10.10) | 16.30 (6.18–31.75) | 0.009 |
| AUC%extrapolated | 1.65 (1.29–2.06) | 1.68 (−11.13–29.84) | 0.14 |
| λz (h−1) | 0.08 (0.08–0.09) | 0.04 (0.03–0.07) | 0.006 |
| AUMC∞ (h x μg/mL) | 93.33 (72.00–118.95) | 393.75 (115.22–3908.18) | 0.009 |
| MRT∞ (h) | 11.30 (10.44–12.19) | 24.16 (12.23–85.36) | 0.006 |
| T1/2 (h) | 8.23 (7.90–8.58) | 17.31 (8.59–64.05) | 0.006 |
| E | 0.008 (0.006–0.01) | 0.004 (0.003–0.006) | 0.009 |
Plasma pharmacokinetic parameters for meloxicam from seven post-partum cows compared to five mid-lactation cows intravenously administered a single dose of meloxicam at 0.2 mg/kg.
Results are presented in geometric means and 95% confidence intervals. P-values are based on non-parametric Wilcoxon Rank Sums 2-sample normal approximation.
Parameters include maximum plasma concentration (Cmax), time of Cmax (Tmax), area under the curve extrapolated to infinity (AUC∞), area under the first momentum curve extrapolated to infinity (AUMC∞), area under the curve percent extrapolated (AUC%extrapolated), slope of terminal phase (λz), terminal half-life (T1/2), volume of distribution (Vd), mean residence time (MRT∞), and clearance (CL).
Table 2. Plasma concentrations (μg/mL) for meloxicam from seven post-partum cows compared to five mid-lactation cows that received intravenous administration of a single dose of meloxicam at 0.2 mg/kg. Results are presented as geometric means and 95% confidence interval.
Table 4. Plasma pharmacokinetic parameters for meloxicam from seven post-partum cows compared to five mid-lactation cows intravenously administered a single dose of meloxicam at 0.2 mg/kg. Results are presented in geometric means and 95% confidence intervals. P-values are based on non-parametric Wilcoxon Rank Sums 2-sample normal approximation.
In the original article, there was a mistake in Table 4 as published. In this table, the units for Vdshould have been L/kg. The corrected Table 4 appears below.
In the original article, there was a mistake in Table 5 as published. In this table, the units for Vz/F should have been L/kg and the values for Vz/F were incorrectly reported as mL/kg. The corrected Table 5 appears below.
Table 5
| Oral | Mid-lactation | Post-partum | P-value |
|---|---|---|---|
| Cmax (μg/mL) | 1.45 (1.12–1.88) | 2.61 (1.79–3.67) | 0.02 |
| Tmax (h) | 10.48 (8.50–12.83) | 16.75 (12.25–22.42) | 0.02 |
| Vz/F (L/kg) | 0.39 (0.27–0.60) | 0.22 (0.17–0.33) | 0.02 |
| CL/F (L/kg/h) | 0.03 (0.02–0.04) | 0.01 (0.007–0.019) | 0.008 |
| AUC∞ (h x μg/mL) | 36.01 (24.29–51.02) | 82.82 (50.55–126.77) | 0.008 |
| AUC%extrapolated | 0.60 (−0.09–1.89) | 0.47 (0.17–0.89) | 0.69 |
| λz (h−1) | 0.07 (0.06–0.08) | 0.06 (0.05–0.07) | 0.05 |
| AUMC∞ (h x μg/mL) | 733.95 (394.66–1194.39) | 2287.61 (981.54–4354.35) | 0.008 |
| MRT∞ (h) | 20.38 (17.16–24.02) | 27.62 (21.56–34.90) | 0.05 |
| T1/2 (h) | 9.55 (8.26–10.99) | 12.28 (9.60–15.42) | 0.05 |
| F (%) | 87.2 | 101.6 | –* |
Plasma pharmacokinetic parameters for meloxicam from six post-partum cows matched to mid-lactation cows orally administered a single dose of meloxicam at 1.0 mg/kg.
Results are presented in geometric means and range. P-values are based on non-parametric Wilcoxon Rank Sums 2-sample normal approximation.
Parameters include maximum plasma concentration (Cmax), time of Cmax (Tmax), area under the curve extrapolated to infinity (AUC∞), area under the curve percent extrapolated (AUC%extrapolated), area under the first momentum curve to infinity (AUMC∞), slope of terminal phase (λz), terminal half-life (T1/2), volume of distribution per fraction of drug absorbed (Vz/F), mean residence time (MRT∞), clearance per fraction of drug absorbed (CL/F), and absolute bioavailability (Fabs).
Statistical comparisons could not be made between treatment groups due individual animals receiving a single treatment and therefore clearance cannot be assumed to be consistent.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Summary
Keywords
meloxicam, pharmacokinetics, post-partum, NSAID, dairy
Citation
Warner R, Ydstie JA, Wulf LW, Gehring R, Coetzee JF, Mochel JP and Gorden PJ (2021) Corrigendum: Comparative Pharmacokinetics of Meloxicam Between Healthy Post-partum vs. Mid-lactation Dairy Cattle. Front. Vet. Sci. 8:665021. doi: 10.3389/fvets.2021.665021
Received
06 February 2021
Accepted
04 May 2021
Published
26 May 2021
Volume
8 - 2021
Edited and reviewed by
Arturo Anadón, Complutense University of Madrid, Spain
Updates
Copyright
© 2021 Warner, Ydstie, Wulf, Gehring, Coetzee, Mochel and Gorden.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Patrick J. Gorden pgorden@iastate.edu
This article was submitted to Veterinary Pharmacology and Toxicology, a section of the journal Frontiers in Veterinary Science
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