ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1476302
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands
Provisionally accepted
- 1College of Animal Science and Technology, Southwest University, Chongqing, Chongqing, China
- 2Leshan Normal University, Leshan, Sichuan, China
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mammary gland, with a pronounced effect compared to QA and ICAB treatment alone. The combined administration of QA and ICAB also effectively suppressed the expression levels of p65, induced by LPS in MAC-T cells and mouse mammary glands, as well as the nuclear translocation of NF-κB in MAC-T cells (p < 0.05). Furthermore, the protein levels of NLRP3 inflammasome (NLRP3, ASC, and caspase-1), caspase-11, and GSDMD were significantly reduced (p < 0.05) compared to QA and ICAB treatment alone.QA and ICAB synergistically inhibits the inflammatory response and pyroptosis in MAC-T cells and mouse mammary glands through modulation of NF-κB pathway and NLRP3 inflammasome. This study contributes novel insights into combination of QA and ICAB in the prevention and treatment of mastitis.
Keywords: Quinic Acid, Isochlorogenic acid B, Mastitis, NF-κB, NLRP3
Received: 20 Aug 2024; Accepted: 19 May 2025.
Copyright: © 2025 Lv, Long, Kang, Lin and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tao Lin, Leshan Normal University, Leshan, 614000, Sichuan, China
Caode Jiang, College of Animal Science and Technology, Southwest University, Chongqing, 400715, Chongqing, China
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