ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Epidemiology and Economics
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1511289
This article is part of the Research TopicEmerging Zoonotic Diseases: Understanding and Mitigating Risks at Animal-Human InterfacesView all 8 articles
Human Papillomavirus in Canine Serum: Evidence from a Chinese Study
Provisionally accepted
- 1Wenzhou University, Wenzhou, Zhejiang Province, China
- 2Guangxi University, Nanning, Guangxi Zhuang Region, China
- 3Guangxi Center for Disease Control and Prevention, Nanning, Guangxi Zhuang Region, China
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Human papillomaviruses (HPVs) are well-known for causing both benign and malignant epithelial growths in humans, but their occurrence in non-human species is rarely reported. In our investigation of serum samples from dogs collected in Guangxi, China, between 2014 and 2020, we unexpectedly detected two strains of HPV with a detection rate of 0.16% (2 out of 1226 samples). Phylogenetic analysis reveals that the canine-origin HPV strain GX-70 is grouped within the same evolutionary branch as alpha2-HPV78, while GX-47 is positioned in the same clade as alpha2-HPV94. Interestingly, both strains displayed multiple amino acid variations. Although virus isolation was not achieved, the detection of HPV nucleic acids suggests the potential presence of HPV in canine hosts. These findings provide new insights into the possible host range of HPV, underscoring the need for further research to assess the virus's infectivity, transmission dynamics, and potential implications for both animal and human health.
Keywords: Papillomavirus (PV), Human papillomavirus (HPV), Canine serum, phylogenetic analysis, Public Health
Received: 16 Oct 2024; Accepted: 14 Apr 2025.
Copyright: © 2025 Liu, Xie, Zhou, Zhou, Bi, Zheng, lan and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Min Zheng, Guangxi Center for Disease Control and Prevention, Nanning, Guangxi Zhuang Region, China
tian lan, Wenzhou University, Wenzhou, 325035, Zhejiang Province, China
Wenchao Sun, Wenzhou University, Wenzhou, 325035, Zhejiang Province, China
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