REVIEW article

Front. Vet. Sci.

Sec. Animal Nutrition and Metabolism

Volume 12 - 2025 | doi: 10.3389/fvets.2025.1544519

Clostridium butyricum: A Promising Approach to Enhancing Intestinal Health in Poultry

Provisionally accepted
  • 1Guizhou Normal University, Guiyang, China
  • 2Hunan Biological And Electromechanical Polytechnic, Changsha, China

The final, formatted version of the article will be published soon.

The intestinal tract is essential forplays a crucial role in the overall health and productivity of animals, including poultry. Clostridium butyricum (C. butyricum) is a probiotic beneficial bacterium that has been shown to be a promising candidate for improving intestinal function and subsequently optimizing poultry growth. The beneficial effects of C. butyricum on intestinal health can be attributed to several key mechanisms. First, it helps maintain the balance of the intestinal microbiota by inhibiting the growth of harmful bacteria and promoting the proliferation of beneficial bacteria. This microbial homeostasis is essential for efficient nutrient digestion and absorptionproper digestion and absorption of nutrients. Second, C. butyricum enhances the integrity of the intestinal barrier. It enhances the integrity of epithelial tight junctionsstrengthens the epithelial tight junctions, reducing the permeability of the intestinal mucosa and preventing the invasion of pathogenic substances. Furthermore, C. butyricum participates in the regulation of immune responses within the intestinal environment. It stimulates the production of immunoglobulins and cytokines, enhancing the immune defense mechanisms of the host. Additionally, C. butyricum influences the metabolism of nutrients in the intestine. It promotes the synthesis of short-chain fatty acids (SCFAs), which pro-vide an energy source for intestinal cells and contribute to maintaining a healthy intestinal environment. Intestinal health is the basis of animal growth, and C. butyricum ultimately enhances production performance in poultrypromotes the production performance of poultry by regulating intestinal health. Studies have demonstrated that the administration of C. butyricum leads to improved feed conversion efficiency, increased weight gain, and enhanced overall production performance in poultry. However, further research is still needed to fully elucidate the complex interactions and precise molecular mechanisms underlying its beneficial effects. Understanding these mechanisms in detail will not only provide important insights for improving poultry production efficiencyvaluable insights for optimizing poultry production but also contribute to the development of more effective and sustainable strategies in the poultry industry.

Keywords: Clostridium butyricum, growth performance, Intestinal health, Intestinal gut microbiota, Poultry

Received: 16 Dec 2024; Accepted: 06 May 2025.

Copyright: © 2025 Tang, Zeng and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Meijun Li, Hunan Biological And Electromechanical Polytechnic, Changsha, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.