REVIEW article
Front. Vet. Sci.
Sec. Veterinary Regenerative Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1571373
This article is part of the Research TopicRegenerative Potential of Natural Products in Veterinary MedicineView all 7 articles
Physiological factors affecting platelet-rich plasma variability in human and veterinary medicine
Provisionally accepted
Rocío Colomer Selva1*
Asta Tvarijonaviciute2
Lorena Franco Martínez2
Ángel Hernández1
José María Carrillo1
Monica Rubio1
Joaquín Jesús Sopena Juncosa1
Katy Satué1- 1Faculty of Veterinary Science, CEU Cardenal Herrera University, Valencia, Spain
- 2University of Murcia, Murcia, Murcia, Spain
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Platelet-rich plasma (PRP) is the fraction of autologous plasma that contains a supraphysiological concentration of platelets, which are an important reservoir of growth factors. PRP is today one of the treatments of choice in regenerative medicine in both humans and animals. The aim of this study was to assess the existing literature on the possible influence of the patient's physiological factors on different PRP characteristics, like platelet concentration, quantity of obtained plasma, quantity and types of growth factors (GFs) in human and veterinary medicines. In addition, a secondary aim was to compare protocols used to prepare PRP in these studies. In a total of 34 studies evaluated, the use of different protocols for the preparation and characterization of PRP and certain physiological factors such as age, sex and body condition substantially modify the characteristics of PRP in both human and veterinary medicine. Therefore, it is essential to standardize PRP collection protocols and define study groups based on physiological factors like sex, age, body mass index (BMI), fertility status and analyzed GFs to ensure reliable data and derive precise, informative conclusions.
Keywords: PRP, Platelet-Rich Plasma, growth factors, age, Sex, BMI, Regenerative Medicine
Received: 05 Feb 2025; Accepted: 05 May 2025.
Copyright: © 2025 Colomer Selva, Tvarijonaviciute, Franco Martínez, Hernández, Carrillo, Rubio, Sopena Juncosa and Satué. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rocío Colomer Selva, Faculty of Veterinary Science, CEU Cardenal Herrera University, Valencia, Spain
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.