ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Anesthesiology and Animal Pain Management
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1581490
Musculoskeletal Adverse Events in Dogs Receiving Bedinvetmab (Librela)
Provisionally accepted
Mike Farrell1*
Felix W.A. Waibel2Ines Carrera3*Giliola Spattini4
Louise Clark5*
Robert J. Adams6Dirsko J.F. von Pfeil7
Ricardo J.R. De Sousa8
Diego Bobis Villagrà9Maria Amengual-Vila8
Annalisa Paviotti10
Rob Quinn11Justin Harper12
Stephen P. Clarke1
Christopher J. Jordan13Michael Hamilton14
Andy P. Moores13
Mark Irwin Greene15- 1Ferguson Veterinary Clinic, Glenrothes, United Kingdom
- 2Department of Orthopaedic Surgery, Balgrist University Hospital, Zurich, Switzerland
- 3Vetoracle Teleradiology, Diss, United Kingdom
- 4Clinica Veterinaria Castellarano, Castellarano, Italy
- 5Davies Veterinary Specialists, Shillington, United Kingdom
- 6Paragon Veterinary Referrals (United Kingdom), Wakefield, United Kingdom
- 7Small Animal Surgery Locum, PLLC, Dallas, Texas, United States
- 8ESPEVET, Mallorca, Spain
- 9Vets Now Limited, Dunfermline, Scotland, United Kingdom
- 10Frank Pet Surgeons, Leeds, United Kingdom
- 11Vita Referrals, Wetherby, United Kingdom
- 12Texas Specialty Veterinary Services, Boerne, United States
- 13The Moores Orthopaedic Clinic, Basingstoke, United Kingdom
- 14Hamilton Specialist Referrals, High Wycombe, United Kingdom
- 15Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
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Adverse drug reaction (ADR); adverse event (AE); adverse event report (AER); anti-NGF monoclonal antibody (aNGFmAb); computed tomography (CT); EudraVigilance database (EVD); European Board of Veterinary Specialisation (EBVS); European Medicines Agency (EMA); Food and Drug Administration (FDA); humeral condylar fracture (HCF); humeral intracondylar fissure (HIF); marketing authorization holder (MAH); magnetic resonance imaging (MRI); medial coronoid process (MCP); musculoskeletal adverse event (MSAE); musculoskeletal adverse event report (MSAER); nerve growth factor (NGF); non-steroidal anti-inflammatory drugs (NSAIDs); osteoarthritis (OA); rapidly progressive osteoarthritis (RPOA); risk evaluation and mitigation strategy (REMS); tibial plateau leveling osteotomy (TPLO); Veterinary Dictionary for Drug-Related Adverse Reactions (VeDDRA); Veterinary Medicines Directorate (VMD).
Keywords: bedinvetmab, Librela, NGF, Rapidly progressive osteoarthritis, RPOA Author 1. Final proof-reading: All authors
Received: 22 Feb 2025; Accepted: 04 Apr 2025.
Copyright: © 2025 Farrell, Waibel, Carrera, Spattini, Clark, Adams, von Pfeil, De Sousa, Villagrà, Amengual-Vila, Paviotti, Quinn, Harper, Clarke, Jordan, Hamilton, Moores and Greene. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mike Farrell, Ferguson Veterinary Clinic, Glenrothes, United Kingdom
Ines Carrera, Vetoracle Teleradiology, Diss, United Kingdom
Louise Clark, Davies Veterinary Specialists, Shillington, SG5 3HR, United Kingdom
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.