ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Emergency and Critical Care Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1585988
Retrospective report of canine serum albumin xenotransfusion in five critically-ill cats
Provisionally accepted
- 1Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States
- 2Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States
- 3VCA West Los Angeles Animal Hospital, Los Angeles, California, United States
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This retrospective case series describes the xenotransfusion of canine serum albumin (CSA) in five critically-ill cats. Four cats each received a single xenotransfusion of CSA, while one cat received two separate xenotransfusions. Overall, two out of five cats (40%) survived to discharge, which is similar to previously published survival rates for critically ill cats. One cat had clinical signs attributable to an acute transfusion-associated circulatory overload (TACO) while two cats had clinical signs of a possible, but less likely, transfusion reaction. While prospective study is needed, review of the cases presented here suggest that CSA might provide oncotic and hemodynamic support and may be safe to administer to critically ill cats.
Keywords: Xenotransfusion, feline, albumin, Hypoalbuminemia, canine albumin
Received: 01 Mar 2025; Accepted: 16 May 2025.
Copyright: © 2025 Sirabian, Walton and Blong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: April Blong, Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, 50011-1134, Iowa, United States
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