REVIEW article
Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1588098
Large animal models in gynaecology: status and future perspectives
Provisionally accepted
- 1The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
- 2Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 3The Third Affiliated Clinical Hospital of Changchun University of Traditional Chinese Medicine, Jilin, China
- 4First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
- 5China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
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The purpose of this review is to evaluate the effectiveness of large animal models in gynecology research and provide future perspectives. Gynaecological diseases are diverse and pose a serious threat to women’s physical and mental health. In addition to the commonly used small animal models, large animal models have gradually entered the field of gynaecological research. Results suggest that large animal models offer significant advantages in simulating human physiological processes, despite ethical and practical challenges. This paper reviews the application of large animal models in the study of gynaecological diseases, provides a summary of the research characteristics of large animal models, analyses the advantages and challenges of these models in disease research, and compares the research differences between large and small animal models. It also discusses the relationship between these models and new alternative models, with a view to providing more new ideas for the selection of animal models in the study of gynaecological diseases.
Keywords: large animal models, Gynaecological diseases, non-human primates, pigs, Sheep
Received: 05 Mar 2025; Accepted: 17 Apr 2025.
Copyright: © 2025 Liu, Zhao, Li, Zheng, Xie and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Liu, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.