ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1588671
This article is part of the Research TopicInnovative Nutritional Technologies for Sustainable Ruminant FarmingView all articles
Relationship between plasma asprosin and dry matter intake, and plasma glucose in different stages of lactation
Provisionally accepted
- 1School of Animal Husbandry and Veterinary Medicine, Jiangsu Vocational College of Agriculture and Forestry, Jurong, China
- 2College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu Province, China
- 33Supervision and testing center for agricultural product quality, Yancheng, China
- 4Bright Farming Co., Ltd., Key Laboratory of Dairy Cattles Genetic Improvement in Southern China Ministry of Agriculture and Rural Affairs, Shanghai, China
- 5Institute of Grassland Research, Chinese Academy of Agricultural Sciences, Hohhot, China
- 6Hangzhou king techina feed co., Ltd, Hangzhou, China
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In postpartum dairy cows, dry matter intake (DMI) was dramatically decreased, resulting in decreased glucose production and negative energy balance (NEB). Asprosin, which is a centrally acting orexigenic protein hormone secreted by adipose tissue, promotes glucose production in liver. However, effect of asprosin on the hepatic glucose output in primary bovine hepatocytes and relationship between plasma asprosin and dry matter intake in different stages of lactation that remains not reported. Our results demonstrated that fibrillin 1 (FBN1) showed much higher mRNA expression in mammary gland and adipose tissue. The bovine His-asprosin proteins were > 90 % pure by Coomassie Blue-stained SDS-PAGE gel analysis. Asprosin enhanced (P = 0.031) the mRNA expression of PCK2 in primary bovine hepatocytes compared with control group. Remarkably, glucose output was increased (P = 0.03) in primary bovine hepatocytes exposed to asprosin than control group. In addition, asprosin can promote PKA activity in primary bovine hepatocytes. The postpartum dairy cows exhibited much lower plasma asprosin level compared to 110 and 230 d relative to parturition (P < 0.01). Notably, plasma asprosin level is positively correlated with DMI in different stages of lactation. These findings indicate that increased circulating asprosin should be further considered as a novel resolution strategy for DMI increase and negative nutrient balance in postpartum period.
Keywords: asprosin, Dry matter intake, Hepatocytes, Gluconeogenesis, Glucose, Postpartum
Received: 06 Mar 2025; Accepted: 29 Apr 2025.
Copyright: © 2025 Chen, Jiang, Li, Su, Luo, Wu, QI, Lin and Zhan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kang Zhan, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu Province, China
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