CLINICAL TRIAL article
Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1590703
Treatment of canine pancreatitis using membrane free stem cell extract (MF-STEM) and its anti-inflammatory effect
Provisionally accepted
- 1Yong animal CTMRI medical center, Changwon, Republic of Korea
- 2The Prime Animal Hospital, Busan, Republic of Korea
- 3T-stem Co. Ltd, Changwon, Republic of Korea
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Canine pancreatitis can lead to digestion of nearby organs and if untreated, it can develop to peritonitis. Therefore early treatment is crucial for the patient's outcome. Widely used treatment as of now for acute pancreatitis (AP), however, largely depends on supportive treatment such as fluid therapy, antibiotics and sufficient nutrient intake. Diagnosis of AP is made with patient history, clinical presentation, blood exams, and diagnostic imaging. Canine specific lipase (cPL) specifically evaluates pancreatitis. C-reactive protein evaluates the inflammatory status of the patient. Abdominal ultrasound can assess the pancreas and its surrounding organs.Membrane-free stem cell extract (MF-STEM) is a protein mixture and other bioactive molecules derived from human adipose stem cells. It involves isolating and culturing human adipose stem cells and extracting the effective ingredients contained within them. MF-STEM is known for its anti-inflammatory and regenerative effects.This study was a vehicle-controlled clinical study. One hundred and forty-five canine patients participated with pancreatitis participated in this study with owners' consent. Following the owners' consent, 63 dogs received MF-STEM cell therapy with conventional therapy and 82 dogs received conventional therapy. All participants had their cPL and CRP measured to evaluate their clinical progression. At the time of discharge, the survival rate in the MF-STEM cell therapy group survived (survival 92%, mortality 8%) more than the control group (survival 46%, mortality 54%). There were no side effects observed, such as allergic reaction and hypersensitivity reaction.
Keywords: canine pancreatitis, acute pancreatitis, Canine specific pancreatic lipase, CPL, C-Reactive Protein, crp, stem cell, Membrane-free stem cell extract
Received: 10 Mar 2025; Accepted: 08 May 2025.
Copyright: © 2025 Choi, Lee, Kim and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yongsoo Choi, Yong animal CTMRI medical center, Changwon, Republic of Korea
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