ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Surgery
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1593434
The impact of anatomical recipient liver abnormalities on rat liver transplantation
Provisionally accepted
- 1Zhengzhou University, Zhengzhou, China
- 2Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
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Background: Orthotopic rat liver transplantation (OLT) is widely used in basic research; normal liver anatomy and structures are attributable to its success, but its deformities are complicated by a negative OLT. Methods: For tolerance induction, we used OLT from Lewis to Brown Norway (BN) rats as a chronic rejection model and encountered two anatomical deformities of recipient livers. The outcomes of OLT were analysed. Results: Of the 47 liver transplantations, the accessory liver lobe occurred in 4 cases, and bifurcations of liver outflow occurred in 5 cases in BN rats.For the accessory liver lobe, we discontinued OLT in one with a large accessory liver lobe. Two rats died from pneumothorax upon separation, and one case succeeded with a small lobe. For two vein outflow orifices of the liver, we succeeded in OLT due to its reconstruction in one case; however, the recipient died one week later in 1 case, after one small orifice was sutured. We failed in 3 cases due to thrombosis following OLT. Among the 38 rats with normal liver anatomy, only 4 failed to survive LT. There were significant differences in OLT success (p<0.01). Conclusion: Recipient liver abnormal anatomical structure has a negative impact on OLT, suggesting that pretransplant comprehensive screening is important and that clinicians are cautious in clinical practice.
Keywords: Orthotopic liver transplantation, liver deformity, Outcome, two liver outflows, liver accessory lobe
Received: 02 Apr 2025; Accepted: 19 Jun 2025.
Copyright: © 2025 Chen, Li, Zhou and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shaotang Zhou, Zhengzhou University, Zhengzhou, China
Guoyong Chen, Zhengzhou University, Zhengzhou, China
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