ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Clinical, Anatomical, and Comparative Pathology
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1595147
This article is part of the Research TopicInnovations in Veterinary Diagnostics for Enhancing Animal Health and WelfareView all 5 articles
Evaluation of Clopidogrel Responsiveness using the Platelet Function Analyzer-200 (PFA-200) in Dogs
Provisionally accepted
- 1Department of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
- 2KU Center for Animal Blood Medical Science, Konkuk University, Seoul, Republic of Korea
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We aimed to evaluate the prevalence of clopidogrel resistance in hypercoagulable dogs using the Platelet Function P2Y cartridge; further, we aimed to assess the utility of hematocrit (HCT), platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (aPTT), thromboelastography (TEG) parameters, and D-dimer level as indicators of clopidogrel efficacy. Forty healthy dogs underwent single measurements of P2Y closure time (CT), HCT, PLT, PT, aPTT, TEG parameters, and D-dimer levels, while thirty hypercoagulable dogs underwent two measurements of these parameters (before and after clopidogrel treatment. The reference interval for P2Y CT in healthy dogs was 40.0-141.5 s, with a mean of 63.9±26.82 s. Hypercoagulable dogs showed a mean baseline P2Y CT of 77.4±37.6 s. Moreover, 23 (76.67%) and 7 (23.33%) showed responsiveness and resistance to the initial clopidogrel dose, respectively. The mean P2Y CT of the clopidogrel-resistant group after clopidogrel administration was 182.71±78.43 s. Increasing the maintenance dose successfully overcame clopidogrel resistance in these seven dogs. Among the assessed parameters, only D-dimer levels showed a significant decrease in the clopidogrel-responder group (p<0.05), suggesting its potential utility in evaluating responsiveness. In conclusion, the PFA-200 P2Y cartridge effectively detects clopidogrel resistance in dogs and can guide therapeutic adjustments such as dose escalation.
Keywords: Platelet function analyzer, PFA, P2Y cartridge, Clopidogrel resistance, Dogs
Received: 01 Apr 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Shin and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hyun-Jung Han, Department of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
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