REVIEW article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1596316
This article is part of the Research TopicReviews in Pathology of Infectious Diseases - Volume IIView all 7 articles
Porcine proliferative enteropathy: Overview of disease dynamics and non-antibiotic alternatives for prevention and control strategies
Provisionally accepted
Luis-Miguel Gómez-Osorio1,2*
Felipe Penagos-Tabares2
Jasna Bosnjak-Neumuller3
Roberto M.C. Guedes4Marko Vasiljevic3Tobias Steiner5
Steven McOrist6- 1Independent researcher, Medellin, Colombia
- 2University of Antioquia, Medellín, Antioquia, Colombia
- 3Patent Co., DOO, Mišićevo, Serbia
- 4Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Mato Grosso, Brazil
- 5AGROMED, Kremsmünster, Austria
- 6Scolexia Pty Ltd, Moonee Ponds, Australia
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Porcine proliferative enteropathy caused by the intracellular bacterium Lawsonia intracellularis remains an economically significant health concern in global pig farming. Clinical and subclinical forms of the disease commonly occur, resulting in substantial productivity losses due to effects on pig growth rate, feed efficiency, and mortality. Current management and control strategies rely primarily on effective vaccines and antibiotics. However, due to antimicrobial resistance being a global public health issue, there is a growing interest in and the need for research, development and large-scale implementation of novel and promising alternatives to antibiotics in animal production. This review integrates current research on novel prevention and management strategies, including current trends in phytotherapy (e.g., phytogenic feed additives), probiotics, prebiotics, immunomodulators, advanced vaccination protocols, and genetic resistance trends in swine. This review also discusses the implementation of biosecurity measures, cost-effectiveness, economic implications, and future perspectives of these strategies.
Keywords: Ileitis, gut health, essential oils, lawsonia intracellularis, lysozyme, Niacinamide, Phytogenics
Received: 19 Mar 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Gómez-Osorio, Penagos-Tabares, Bosnjak-Neumuller, Guedes, Vasiljevic, Steiner and McOrist. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Luis-Miguel Gómez-Osorio, lgomezosorio@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.