ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Clinical, Anatomical, and Comparative Pathology
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1603620
This article is part of the Research TopicInnovations in Veterinary Diagnostics for Enhancing Animal Health and WelfareView all 3 articles
Frequency domain analysis of steady-state visual evoked potentials (SSVEP) in dogs with optic neuritis: A pilot study
Provisionally accepted
Teck-Geun Lee
Joon Young Kim*- Konkuk University, Seoul, Republic of Korea
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Visual evoked potentials (VEP) are electrophysiological signals used to assess visual pathway function, with applications in diagnosing optic nerve disorders. This study compared the diagnostic utility of transient VEP (TVEP) and steady-state VEP (SSVEP) in dogs with optic neuritis, focusing on SSVEP's frequency-domain advantages. Seven dogs with optic neuritis and seven controls matched for breed, age, and weight were evaluated. TVEP and SSVEP were recorded without anesthesia using standardized protocols, and parameters were analyzed in time and frequency domains. Significant reductions in SSVEP Frequency-Domain amplitude (FD amplitude), Time-Domain amplitude (TD amplitude), and Signal-to-Noise Ratio (SNR) were observed in the optic neuritis group (FD amplitude: p < 0.001, TD amplitude: p < 0.001, SNR: p < 0.001). TVEP N1-P2 amplitude was also significantly lower in the optic neuritis group (p < 0.001), while P2 latency showed no significant differences. Indirect comparisons revealed that TVEP amplitudes were larger, likely due to noise artifacts in time-domain analysis. SSVEP demonstrated superior noise resistance and minimized subjective interpretation. These results suggest SSVEP's potential as a reliable, noninvasive diagnostic tool for optic neuritis in dogs, with further studies needed to confirm its broader applications in veterinary ophthalmology.
Keywords: Optic Neuritis, Steady-state visual evoked potentials, Transient visual evoked potentials, signal-to-noise ratio, Response amplitude
Received: 31 Mar 2025; Accepted: 06 Jun 2025.
Copyright: © 2025 Lee and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Joon Young Kim, Konkuk University, Seoul, Republic of Korea
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