BRIEF RESEARCH REPORT article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1603997
Magnolia officinalis enhanced immune responses and the resistance to Vibrio harveyi infection in pearl gentian groupers
Provisionally accepted
- 1Guangdong Ocean University, Zhanjiang, China
- 2Shenzhen Research Institute of Guangdong Ocean University, Shenzhen, China
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Magnolia officinalis (MO) is a kind of traditional Chinese herbs, which has been studied for thousands of years in Chinese pharmacopoeia. In recent years, MO has been reported as an antibacterial agent in aquaculture, but the antibacterial properties of MO against Vibrio harveyi infection in fish remains unexplored. In this study, the effects of MO treatment on immune responses and the resistance to V. harveyi infection were detected in pearl gentian groupers. The results revealed that the expression levels of immune-related genes (IL-12, TLR2, TLR5S, CD4, MHC-Iα, and IFN-γ) in spleen, head kidney, liver and thymus, and the enzyme activities of CAT, SOD, LZM, and total serum protein in serum were significantly up-regulated at most of time points in MO -treated groupers. After being challenged with V. harveyi ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0%, 60.0%, 73.3%, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to V. harveyi infection in groupers. The present study revealed that MO can be considered as a promising immunostimulant to induce the immune responses against V. harveyi infection in marine fishes.
Keywords: Magnolia officinalis, Vibrio harveyi ZJ0603, pearl gentian groupers, immune response, Immunostimulant
Received: 02 Apr 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Zhang, Li, Xu, Xu, Li, Gan and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhen Gan, Guangdong Ocean University, Zhanjiang, China
Yishan Lu, Guangdong Ocean University, Zhanjiang, China
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