ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1610218
This article is part of the Research TopicBioactive Natural Compounds and Their Role in Oxidative Stress in AnimalsView all articles
Antioxidant Activity of Jinxuan Tea Polysaccharide and its Protective Effect on Intestinal Injury Induced by Transport Stress in Chicks
Provisionally accepted
- 1South China Agricultural University, Guangzhou, China
- 2Tea Research Institue, Guangdong Academy of Agricultural Sciences (GDAAS), Guangzhou, Guangdong Province, China
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Transport stress (TS) is unavoidable for livestock and poultry in modern agriculture, which not only affects animal welfare, but also to the quality of meat products. Tea polysaccharide (TPS), one of the major bioactive components of tea leaves, has been shown to have anti-stress effects. However, the antagonistic effect of TPS on TS-induced intestinal damage in chicks is unclear. This study investigated the antioxidant activity of TPS and its effect on intestinal injury induced by TS in chicks. The results showed that TPS had good free radical scavenging ability and reducing ability. We established an oxidative damage model of cells using H₂O₂ and found that TPS could significantly alleviate cell oxidative damage induced by H2O2. In vivo test results showed that the TS-induced intestinal pathological damage and oxidative damage were markedly alleviated by TPS. Furthermore, TS resulted in the elevated expression of heat shock factors, disrupted expression of heat shock proteins, and similarly disrupted expression of aquaporins in chicks. Surprisingly, chicks treated with TPS showed a significant decrease in the expression of heat shock factors and significant alleviation of the dysregulated expression of heat shock proteins and aquaporins. Analysis of the intestinal flora showed that TS resulted in reduced intestinal flora diversity and altered flora structure in chicks, whereas the intestinal flora was normalized after TPS intervention. In conclusion, TPS has good antioxidant activity and significantly ameliorate TS-induced intestinal damage in chicks, suggesting that TPS could be developed and utilized as a feed additive.
Keywords: Tea polysaccharide, antioxidant activity, Transport stress, Intestinal injury, intestinal flora
Received: 07 May 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Sun, Zhou, Gao, Liu, Zhao, Ling and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Binghu Fang, South China Agricultural University, Guangzhou, China
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