MINI REVIEW article
Front. Vet. Sci.
Sec. Animal Reproduction - Theriogenology
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1617740
This article is part of the Research TopicRecent developments in Animal Reproduction: combining research with practiceView all 15 articles
Nature Does It Better: Mimicking In Vivo Conditions to Resolve In Vitro Production (IVP) Side Effects
Provisionally accepted
- 1Department of Animal Medicine, Production and Health, School of Agricultural Sciences and Veterinary Medicine, University of Padua, Padua, Italy
- 2Department of Animal Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Ankara University, Ankara, Türkiye
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Oviduct represents the original place of fertilisation and early embryo development in all the domestic animals. In past time it has been considered a mere channel but new reproductive biotechnology approaches suggested the need of structurally and functionally efficient oviductal environment for in vitro embryo production. Recreating the oviductal microenvironment in IVP systems represents a paradigm shift in reproductive biotechnology. By incorporating reproductive fluids and utilising advanced 3D culture models could be reduced adverse IVP outcomes, and bring assisted reproduction closer to its natural counterpart.
Keywords: Oviductal fluid, in vitro production IVP, Large offspring syndrome, embryos, extracellular vesicles, 3D cell culture
Received: 24 Apr 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Dalle Palle, Tekin and Stelletta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Enrico Dalle Palle, Department of Animal Medicine, Production and Health, School of Agricultural Sciences and Veterinary Medicine, University of Padua, Padua, Italy
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