ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1618962
Prevalence and genetic diversity of Porcine reproduction and respiration syndrome viruses in Sichuan Province from 2023-2024
Provisionally accepted
- 1College of Animal Science, Xichang University, Xichang, China
- 2Key Laboratory of Animal Epidemic Disease Detection and Prevention in Panxi District, Sichuan, China
- 3Academy of Agricultural Sciences of Liangshan Yi Autonomous Prefecture, Xichang, China
- 4Agricultural and Rural Bureau of Liangshan Yi Autonomous Prefecture, Xichang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Porcine reproductive and respiratory syndrome (PRRS), caused by porcine reproductive and respiratory syndrome virus (PRRSV), occurs frequently in China, and severely hinders the healthy development of the pig farming industry. To determine the genetic diversity and epidemiological characteristics of PRRSV strains in Sichuan Province, we collected 499 clinical samples suspected of PRRSV infection from 101 pig farms in 19 cities from 2023 to 2024. Among the 499 samples, 162 were positive for PRRSV, with a total prevalence of 32.46% according to RT-qPCR. Among the 101 pig farms, 55 were positive farm, resulting in a rate of 54.46%. Further analysis of the complete ORF5 gene sequences of 56 PRRSV strains revealed that they could be classified into six lineages: PRRSV-1, lineage 8 (HP-PRRSV), lineage 5 (Classical PRRSV), lineage 1.8 (NADC30-like strain), lineage 1.5 (NADC34-like strain), and lineage 3.5 (QYYZ-like strain). Notably, both the lineage 8 and PRRSV-1 strain were detected in the same sample, indicating the presence of mixed infection. This study revealed the coexistence of multiple lineages of PRRSV in Sichuan Province, with the lineage 1.8 emerging as the predominant epidemic lineage. The concurrent prevalence of multiple lineages underscores the importance of selecting matching vaccines on the basis of locally prevalent strains and the need for continuous epidemiological monitoring of PRRSV.
Keywords: Porcine reproductive and respiratory syndrome virus (PRRSV), phylogenetic analysis, lineage 1.8, PRRSV-1, ORF5
Received: 27 Apr 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Li, Wang, Li, Zhou, Hu, Bai, Hao and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guangwen Yan, College of Animal Science, Xichang University, Xichang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.