Clinical and histopathological investigation of the possible occurrence of tracheobronchial disease in cats with chronic gingivostomatitis

Olga Lorida^1*Alexandros Konstantinidis¹Georgia D Brellou²Georgia Koutouzidou³Paraskevi Papadopoulou⁴Apostolos Matiakis⁵Katerina K Adamama-Moraitou¹Serafeim Papadimitriou¹

• ¹Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
• ²Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
• ³Department of Agriculture, School of Agricultural Sciences University of Western Macedonia, Florina, Greece
• ⁴Laboratory of Diagnostic Imaging, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
• ⁵Department of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece

Introduction: Feline chronic gingivostomatitis is a debilitating and highly painful inflammatory disorder of the feline oral cavity. Evidence suggests that Feline Chronic Gingivostomatitis (FCGS) induces systemic effects that extend beyond localized oral pathology, contributing to overall health decline in affected cats. The aim of this study was to investigate the potential impact of FCGS on the lower respiratory tract.Methods: This is a prospective study, that included forty-two cats with clinical signs of FCGS and five healthy control cats exhibiting no signs of oral disease. All cats underwent physical, oral and endoscopic examinations of the lower respiratory tract. Radiological evaluation of the thorax was also performed. Lesions in the respiratory tract detected upon endoscopy and the oral cavity were recorded and scored. In cats with FCGS biopsies from bronchial mucosa were obtained from sites showing endoscopic evidence of inflammation.Results: Respiratory lesions were identified in all FCGS cats included in the study. Specifically, secretions were detected in 42 out of 42 (100%) cats, bronchial mucosal edema in 33 out of (78.6%), a granular appearance in 14 out of 42 (33.3%), and hyperemia in 11 out of 42 (26.2%). Histopathological examination revealed mucosal and submucosal inflammation in 30 out of 36 (83.3%) cats and mucosal edema in 25 out of 36 (69.4%). Additionally, fibrosis was observed in 25 out of 36 (69.4%) samples, hyperplasia or dilatation of bronchial glands in 8 out of 36 (22.2%), and vascular wall thickening in 11 out of 36 (30.5%). Bronchial smooth muscle hypertrophy was present in 22 out of 36 (61.1%) examined samples. An attempt to correlate oral and respiratory lesion severity found no statistically significant correlation between stomatitis index, tracheobronchoscopy, or histopathological scores.Discussion: FCGS appears to coexist with lower respiratory tract disease. During FCGS management, it might be essential to address any underlying respiratory disorder, as it may favour the outcome of the primary disease, while remaining unattended it may increase the likelihood of FCGS recurrence.