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REVIEW article

Front. Vet. Sci.

Sec. Oncology in Veterinary Medicine

Volume 12 - 2025 | doi: 10.3389/fvets.2025.1633593

Osteosarcoma of the Appendicular Skeleton in Dogs: Consensus and Guidelines

Provisionally accepted
Gerry  PoltonGerry Polton1*Juan  F BorregoJuan F Borrego2Pachi  Clemente-VicarioPachi Clemente-Vicario3Craig  Andrew CliffordCraig Andrew Clifford4Dariusz  JagielskiDariusz Jagielski5Martin  KesslerMartin Kessler6Tetsuya  KobayashiTetsuya Kobayashi7Didier  LANOREDidier LANORE8Felisbina  L QueirogaFelisbina L Queiroga9Lucas  RodriguesLucas Rodrigues10Annika  Tranaeus-RoweAnnika Tranaeus-Rowe11Péter  VajdovichPéter Vajdovich12Philip  J BergmanPhilip J Bergman13
  • 1North Downs Specialist Referrals, Bletchingley, United Kingdom
  • 2Hospital Aúna Especialidades Veterinarias IVC-Evidensia, Valencia, Spain
  • 3La Merced Veterinary Specialists, Calpe, Alicante, Spain
  • 4Bluepearl, Malvern, PA, United States
  • 5Veterinary Institute, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Toruń, Poland
  • 6Department of Clinical Oncology, Tierklinik Hofheim, Hofheim, Germany
  • 7Japan Small Animal Cancer Center, Tokorozawa City, Japan
  • 8Oncology Unit, Clinique Hopia, Guyancourt, France
  • 9Universidade de Tras-os-Montes e Alto Douro, Vila Real, Portugal
  • 10Estima Diagnósticos e Especialidades, Taubaté, SP, Brazil
  • 11Evidensia Specialist Animal Hospital Strömsholm, Strömsholm, Sweden
  • 12Department of Physiology and Oncology, University of Veterinary Medicine, Budapest, Hungary
  • 13Veterinary & Cancer Immunotherapy Programs, Focused Ultrasound Foundation, Charlottesville, VA, United States

The final, formatted version of the article will be published soon.

Osteosarcoma (OSA) in dogs poses a clinical challenge to veterinary practitioners across the globe. As knowledge evolves, so too do clinical practices. However, there remain uncertainties and controversies. There is value for the veterinary community at large in the generation of a contemporary wide-ranging guideline document. The aim of this project was therefore to assimilate the available published knowledge into a single accessible referenced resource and to provide expert clinical guidance to support professional colleagues as they navigate current OSA challenges and controversies. Primary bone tumors are common in dogs. The history and clinical signs relate to the anatomic site of the tumor. Most canine patients present with a sudden-onset lameness that can appear to improve temporarily in response to analgesia and rest. Most patients do not have detectable metastasis at the time of diagnosis, but most canine patients do develop metastasis within months without appropriate therapy. Surgical resection using wide margins is currently the mainstay of therapy for the local control of the primary tumor. Most commonly, this comprises limb amputation in dogs, but not all dogs are considered good candidates. Anti-metastatic therapy is vital in dogs if surgery is going to offer a good chance of achieving a durable benefit. While there are many limb-sparing and palliative therapy options for dogs with OSA, most have not been shown to achieve superior outcomes compared with amputation and adjuvant chemotherapy. There is a role for radiotherapy in the palliative treatment of OSA. Immunotherapy should be considered a developing treatment modality – multiple immunotherapeutic approaches have yielded positive results in dogs in small experimental studies. It is hoped that this document will serve as a useful resource to practitioners all over the world, to help them better understand this disease and provide the best options for patients to extend quality of life and survival, either within the primary care or referral hospital setting.

Keywords: Osteosarcoma, guidelines & recommendations, canine, Treatment, prognosis

Received: 22 May 2025; Accepted: 01 Sep 2025.

Copyright: © 2025 Polton, Borrego, Clemente-Vicario, Clifford, Jagielski, Kessler, Kobayashi, LANORE, Queiroga, Rodrigues, Tranaeus-Rowe, Vajdovich and Bergman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Gerry Polton, North Downs Specialist Referrals, Bletchingley, United Kingdom

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.