REVIEW article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1635245
Zeolite for Preventing Periparturient Hypocalcemia in Dairy Cows: Mechanisms and Application Strategies
Provisionally accepted
- China Agricultural University, Beijing, China
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This review provides a comprehensive and systematic overview of the existing literature on the use of zeolites in the prevention of postpartum hypocalcemia in dairy cows, while also incorporating recent research findings relevant to this topic. It examines potential mechanisms of action-such as the phosphate-FGF23 -Klotho axis and the serotonin-PTHrP-calcium axis-before discussing practical feeding strategies for zeolite application. Related effects on rumen fermentation and immune responses are also briefly discussed. A comparative overview of different zeolite types, dosages, and particle sizes is included to support future research and on-farm application. We believe this work aligns with the scope of Frontiers in Veterinary Science, especially within the fields of animal nutrition and metabolic health, and may serve as a useful reference for researchers and practitioners in veterinary science.
Keywords: Jie Cao: Conceptualization, Funding acquisition, Writing -review & editing. Yuanyin Guo: Data curation, Writing -original draft. Pengyu Huang: Data curation, Writing -original draft. Xiu Su: Data curation, Writing -original draft, Writing -review & editing zeolite, Transition dairy cows
Received: 26 May 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Su, Huang, Guo and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Cao, China Agricultural University, Beijing, China
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