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ORIGINAL RESEARCH article

Front. Vet. Sci.

Sec. Oncology in Veterinary Medicine

Volume 12 - 2025 | doi: 10.3389/fvets.2025.1649599

B-Cells and Non-B-cells Immunoglobulins Expression in Canine Perianal Gland Tumours: A Preliminary study

Provisionally accepted
  • 1Department of Veterinary Sciences, University of Messina, Messina, Italy
  • 2St Vincent Health Care Group-UCD, Dublin, Ireland
  • 3Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Pathology, University of Messina, Messina, Italy

The final, formatted version of the article will be published soon.

Although the focus in tumor immunology has been on T cells, B cells may play a crucial role in modulating tumor responses. Among products released in the tumour microenvironment, Immunoglobulins (Igs) have been associated with the development and progression of various types of human cancer. However, their role in veterinary oncology has yet to be fully investigated. It has long been widely acknowledged that Igs are produced solely by B-lineage cells. However, several studies have shown that Ig is also expressed by many normal and pathological "non-B" cells, including neoplastic cells. The aim of this study was to investigate the role of B-cells and Igs in tumours of the canine hepatoperianal glands. Immunohistochemical analysis of ten perianal hepatoid adenomas, thirteen well-differentiated hepatoid carcinomas and nine undifferentiated hepatoid carcinomas revealed that adenomatous structures exhibit the greatest concentration of CD79a-positive, IgA-producing B cells. In contrast, in malignant tumours, an inverse association was observed between CD79a expression and the presence of IgG, accompanied by a significant increase in tumour antigen-specific IgG. These results suggest that IgG produced by neoplastic cells could contribute to tumour progression behavior, potentially serving as prognostic biomarkers and therapeutic targets.

Keywords: perianal gland tumours, epithelial IgG, B-cells, immunoglobulin, cancer-derived Ig, dog

Received: 18 Jun 2025; Accepted: 04 Sep 2025.

Copyright: © 2025 Rifici, LUSI, Giambrone, Ieni, Napoli, Mannarino, Zappone and Mazzullo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Elena Angela LUSI, St Vincent Health Care Group-UCD, Dublin, Ireland
Viola Zappone, Department of Veterinary Sciences, University of Messina, Messina, Italy

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