ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1658719
This article is part of the Research TopicTranslational Research in Veterinary Medicine: Comparative Insights and ApplicationsView all articles
Commercial amniotic membrane extract eye drops for canine SCCED: a retrospective clinical evaluation
Provisionally accepted
- Clinical veterinary medicine, Nanjing Agricultural University, Nanjing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objectives: This study aims to evaluate the efficacy of amniotic membrane extract eye drops (AMEED) in promoting the healing rate of SCCED after cotton-tip debridement (CTD) in dogs.A retrospective review was conducted on the medical records of dogs with SCCED from October 2021 to December 2024. Cases treated with AMEED following CTD (AMEED group), as well as those treated with CTD alone (CTD group), were selected for further evaluation. Data analyzed included age, sex, breed, medical therapies and procedures used, time to healing, performance of a second procedure, and complications.Results: A total number of 20 eyes from 18 dogs were included in the analysis. Eleven eyes of ten dogs were in the CTD group, whereas nine eyes of eight dogs were in the AMEED group. The healing rates were 27.2% (3/11) in the CTD group and 77.8% (7/9) in the AMEED group following a single CTD procedure. The mean time of healing following a single CTD procedure was 16.6 days (range: 11-21 days) in the AMEED group and 10.6 days (range: 7-14 days) in the CTD group, respectively. The longer healing time in the AMEED group may be due to more chronic cases and the presence of corneal granulation tissue compared to the CTD group. A second procedure was performed on two eyes in the AMEED group and five eyes in the CTD group that failed to heal after one procedure. For the eyes that healed in both groups, no complications were observed.Topical therapy with AMEED is a safe and effective adjuvant treatment for canine SCCED. AMEED may be preferred in situations where more invasive procedures are less favorable.
Keywords: Amniotic membrane extract, Corneal defects, Corneal erosion, Ocular surface disease, Ophthalmic solution
Received: 03 Jul 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Luo and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenlei Zhou, Clinical veterinary medicine, Nanjing Agricultural University, Nanjing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.