ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1661103
sIFITM1, sIFITM3, and sViperin antiviral proteins as inactivated CSFV vaccine adjuvants
Provisionally accepted
- Fujian Agriculture and Forestry University, Fuzhou, China
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Vaccine adjuvants enhance vaccine efficacy by improving antigen delivery, reducing antigen requirements, and strengthening the host immune response elicited by vaccines. Currently, adjuvants are extensively utilized in vaccine development, particularly for inactivated or novel genetically engineered vaccines, which often require adjuvant support to achieve optimal performance. Interferon-Inducible Transmembrane Proteins (IFITMs) and Viperin are key members of the Interferon-Stimulated Genes (ISGs) family and play crucial roles in immune regulation. They exhibit broad-spectrum antiviral activity and have emerged as promising research targets. Given the significant antiviral and immune-modulatory functions of IFITMs and Viperin, this study investigated the in vitro expression of porcine ISGs and evaluated their potential as vaccine adjuvants. This research provides a scientific foundation for further research and development of IFITM1, IFITM3, and Viperin as veterinary adjuvants, offering valuable insights into their functional studies.
Keywords: IFN-stimulated genes (ISGs), Antiviral proteins, Inactivated CSFV vaccine, vaccine adjuvants, Protection efficiency
Received: 08 Jul 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Liu, Zhou, Ye, Qiu, Gu, Xu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shasha Liu, Fujian Agriculture and Forestry University, Fuzhou, China
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