ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1667394
Tunneling nanotubes provide a new route for bovine viral diarrhea virus spreading
Provisionally accepted
Jiying YinZehui ZhouNing HeHongming ZhouXiaoqun LiuYixing ZhaoLongge ZhaoJiating ZhangYanan Zhu
Ying Zong
Nai-Chao Diao
Kun Shi
Rui Du*- Jilin Agriculture University, Changchun, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Bovine viral diarrhea virus (BVDV) is one of the major pathogens currently endangering the world's cattle industry. It poses serious difficulties in prevention and treatment because it can infect cattle of all ages and the specific mechanism of its cell-to-cell transmission has not yet been fully clarified. Tunneling nanotubes (TNTs) are F-actin-rich tubules that connect to the cytoplasm of nearby cells. They have been found to play an important role in the transmission of several viruses, but studies on BVDV in TNTs have not been reported. We first report that BVDV can induce the formation of tunneling nanotubes and exploits this route to spread to uninfected cells. Our data highlight a previously unknown route of BVDV spreading, which could have significant implications for celler transmission and immune evasion.
Keywords: bovine viral diarrhea virus, tunneling nanotubes, f-actin, cellertransmission, Immune Evasion
Received: 16 Jul 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Yin, Zhou, He, Zhou, Liu, Zhao, Zhao, Zhang, Zhu, Zong, Diao, Shi and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rui Du, durui197101@sina.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.