CASE REPORT article
Front. Vet. Sci.
Sec. Veterinary Surgery
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1678285
This article is part of the Research TopicPrecision Diagnosis and Targeted Therapies in Companion Animal OncologyView all articles
Case report: Primary Leiomyosarcoma of the Canine Gallbladder with Intraoperative Indocyanine Green Near-Infrared Fluorescence Imaging
Provisionally accepted- 1Department of Veterinary Surgery, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea
- 2Laboratory of Veterinary Surgery & Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea
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A 13-year-old castrated male, Maltese was presented for abnormal findings of gallbladder on abdominal ultrasonography without clinical signs. Abdominal ultrasonography revealed a severely distended gallbladder and a heterogeneous echogenic mass in the gallbladder neck. No evidence of metastasis was observed. Cholecystectomy was performed with indocyanine green near-infrared fluorescence imaging for real-time visualization of the biliary tract that contributed to improve surgical outcomes. In the histopathological examination and immunohistochemical analysis using smooth muscle actin staining, the gallbladder mass was confirmed as a leiomyosarcoma. The patient has been followed up for 18 months without any signs of recurrence or metastasis. This is the first reported case of gallbladder leiomyosarcoma in dogs. Leiomyosarcoma should be considered a differential diagnosis for dogs with gallbladder mass. The histologic low grading, the absence of microscopic residual tumor and metastasis relate to good prognosis.
Keywords: canine, Gallbladder, Leiomyosarcoma, Indocyanine Green, Near-infraredfluorescence
Received: 02 Aug 2025; Accepted: 06 Oct 2025.
Copyright: © 2025 Yun, Kim, Park and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sungin Lee, sunginlee@cbnu.ac.kr
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