REVIEW article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1680448
Interplay Between Nutrition, Microbiota, and Immunity in Rotavirus Infection: Insights from Human and Animal Models
Provisionally accepted
- 1Henan University of Animal Husbandry and Economy, Zhengzhou, China
- 2Washington University in St Louis Department of Molecular Microbiology, St. Louis, United States
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Rotavirus (RV) remains a leading cause of severe gastroenteritis in infants and young animals worldwide, contributing to significant morbidity and mortality despite the availability of vaccines. The gastrointestinal tract's health, shaped by complex interactions between nutrition, the gut microbiota, and the host immune system, plays a crucial role in RV pathogenesis and outcomes. Emerging evidence suggests that dietary components not only influence the composition and function of the gut microbiota but also modulate immune responses essential for protection against RV. This review integrates findings from human and animal models to elucidate the interplay between nutrition, microbiota, and immunity in the context of RV infection. We aim to shed light on the mechanisms by which dietary factors and microbial communities influence RV susceptibility and severity, and how this knowledge could guide the development of more effective preventive and therapeutic strategies.
Keywords: nutrition, microbiota, Immunity, RV, gut health
Received: 06 Aug 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Huo, Qiao, Li, Li and Che. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenying Huo, Henan University of Animal Husbandry and Economy, Zhengzhou, China
Enkai Li, Washington University in St Louis Department of Molecular Microbiology, St. Louis, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.