ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 | doi: 10.3389/fvets.2025.1697499
Effective control of the emerging PEDV G2-c variant with an inactivated autogenous vaccine
Provisionally accepted
Huan Xu1Haichao Wu1Juanjuan Min1Ningning Fu1Ying Shi1Ping Zhou1Mingwei Wang1Ang Shi2Yushuang Zhou2Jinhua Chen1Yuli Hu1*Wen Sun1*
Taotao Yang3*- 1Sinopharm Animal Health Corporation Ltd., Wuhan, China
- 2Sinopharm Animal Health Corporation Ltd., Wuhan 430073, China., Wuhan, China
- 3Yichun University, Yichun, China
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Background Porcine epidemic diarrhea virus (PEDV) is one of the most significant pathogens threatening the swine industry, causing severe economic losses in China. PEDV exhibits a high mutation rate, which may compromise the protective efficacy of currently available commercial vaccines. Results This report describes a PED outbreak occurring from February to April 2025 in a southern Hunan swine farm, resulting in approximately 3000 neonatal piglet deaths within one week of birth. We isolated a PEDV strain (XWF/2025) from infected piglet intestinal contents, which phylogenetic analysis classified within the G2-c subgroup. An inactivated autogenous vaccine using intestinal tissues from infected piglets was rapidly developed, evaluated and administered to all sows in the affected unit. Remarkably, piglet mortality rates decreased significantly within two weeks post-vaccination. Serological analysis demonstrated substantial increases in anti-PEDV neutralizing antibody titers following vaccination compared to pre-immunization levels. This represents a successful application of an autogenous inactivated vaccine for emergency PED control, providing a safe and effective approach. Conclusions Our findings offer valuable insights for combating PED outbreaks through rapid, farm-specific vaccine development.
Keywords: Porcine epidemic diarrhea virus, Autogenous vaccine, Control, G2-c variant, Herd immunity
Received: 02 Sep 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Xu, Wu, Min, Fu, Shi, Zhou, Wang, Shi, Zhou, Chen, Hu, Sun and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuli Hu, huyuli1@sinopharm.com
Wen Sun, sunwen3@sinopharm.com
Taotao Yang, yangtt@jxycu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.