ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Reproduction - Theriogenology
Clinical Significance of the Overgrown Follicles in Dromedary Camels: Prevalence, Risks, Hemodynamics and Response to Prostaglandin F2α
Provisionally accepted
- Qassim University, Al-Melida, Saudi Arabia
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Aim: This study investigated the prevalence, associated risk factors, hemodynamic characteristics, and response to prostaglandin F₂α (PG) of overgrown follicles (OVGF) in dromedary camels. Materials and Methods: In Experiment 1, 338 females were examined for breeding soundness during the breeding season to determine the prevalence and risk factors of OVGFs (>2 cm in diameter). In Experiment 2, 45 females were categorized by follicular structure and scanned with spectral Doppler ultrasonography. In Experiment 3, 14 barren females with OVGFs were given PG treatment and monitored for hormonal changes and fertility outcomes. Results: OVGFs were found in 16.6% of the camels examined, with single (55.5%), double (35.7%), and triple (8.9%) follicles. The majority of affected ovaries contained growing or mature follicles (60.6%) or corpora lutea (3.7%), while 35.7% lacked any additional structures. OVGFs were linked to ovarian hydrobursitis (OVHB, 50%), clinical endometritis (CE, 35.7%), normal genitalia (12.5%), and pregnancy (1.8%). Significant risk factors were OVHB (OR = 27.5; P = 0.002) and CE (OR = 24.7; P = 0.004). Larger and trabeculated OVGFs showed increased systolic and diastolic velocities, a lower resistive index, and a different pulsatility index, indicating improved vascularization with follicular advancement. Complete regression followed by conception occurred in 2/14 animals, partial regression in 8/14 (with one conception), and no regression in 4/14, indicating a limited response to PG therapy. PG administration increased estradiol-17β levels but did not significantly impact progesterone or prolactin levels. Conclusion: In conclusion, overgrown follicles are relatively frequent in dromedary camels and are frequently associated with genital pathologies, particularly ovarian hydrobursitis and endometritis. Their variable vascularization and limited response to prostaglandin treatment suggest that OVGFs may be a persistent follicular condition with low therapeutic reversibility, which has implications for camel fertility management.
Keywords: Camelid reproduction, Ovary, Follicular pathology, prostaglandin, Ultrasonography, Blood, Infertility
Received: 12 Oct 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Ali, Derar and Alharbi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ahmed Ali, drahmedali77@gmail.com
Yousef Alharbi, yhrby@qu.edu.sa
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