Research Topic

Antimicrobial Resistance and Novel Antimicrobial Engineering

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About this Research Topic

Antimicrobial resistance is one of the major threats to global health, food security and development today. The emergence of super bugs and pan-resistant bacterial pathogens, as well as a shrinking pipeline of antibiotics and ineffective therapy in the face of multi-drug resistant pathogens underscores the ...

Antimicrobial resistance is one of the major threats to global health, food security and development today. The emergence of super bugs and pan-resistant bacterial pathogens, as well as a shrinking pipeline of antibiotics and ineffective therapy in the face of multi-drug resistant pathogens underscores the need to design and engineer new antibiotics and antibiotic classes.

In this Research Topic, we are inviting manuscripts that provide novel and innovative therapeutic solutions to address antimicrobial resistance. We seek to receive original research, reviews and perspectives that describe unconventional antibiotics and approaches, including, but not limited to, the use of synthetic biology, nano-biotechnology, nucleic acid therapies, probiotics, phage therapies, immune therapy and small molecule-based approaches.

We are also interested in receiving papers that provide systems biology insights into adaptive resistance evolution, persister formation, gut microbiome ecology and how it impacts antibiotic resistance. We also welcome perspectives from industry experts about the current state of antibiotic development, and changes needed for fostering replenishment of the antibiotic pipeline. Emphasis will be given to novel antimicrobials and engineering approaches, as well as the characterization and treatment of multi-drug resistant bacteria.


Keywords: Antimicrobial Resistance, Multi-Drug Resistance, Clinical Isolates, Adaptive Resistance


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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