About this Research Topic
Cardiovascular regenerative medicine does not limit to the mostly investigated atherosclerotic heart disease, but also involves several other disease entities, such as myocardial fibrosis of any reason, pediatric and adult heart failure or heart valve diseases or congenital or acquired vasculopathies. Recent most advanced technologies, such as organoids, organ-on-a-chip or 3D tissue printing technologies allow to assess the intrinsic regenerative potential of the mammalian, also human heart.
The human heart is composed of several and multiple cell types, including cardiomyocytes, endothelial and other vascular cells, neurons, or various cardiomyocyte subpopulations such as sinoatrial or atrioventricular nodal cells or Purkinje cells. Similarly, vascular structure contains pericytes, smooth muscle cells, or adventitial or endothelial cells. Cell-derived 3D vascular or cardiac organoids or valves may recapitulate the structure and function of the cardiovascular organs, and enable investigations of 1) physiology and pathophysiology of diseases, 2) interaction between cell types and structures, 3) structure abnormalities in developing phase, 4) toxicity prediction by using certain drugs, 5) single cell -omics of selected cells of the 3D structure, 6) 3D printing technologies of the components of the cardiovascular system, 7) manufacturing gene and cell-therapy off-the shelve products.
We welcome the contributions of Original Research Articles, Reviews, Methods, Mini-Reviews and Perspectives regarding 3D structures, which might include, but not limited to:
• Demonstrating 3D organoids structure and developmental technologies
• Presentation on cardiovascular 3D printing methods and results
• Description and function of Organs-on-chips models
• Engineered vasculature, heart valves and bioengineered cardiovascular devices
• Computational design, microsystems and molecular engineering technologies in cardiovascular research
Keywords: Organoid, Organs-on-chips, Engineered Vascular and Valve Structures, Regenerative Medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.