Research Topic

Engineering Nucleic Acids-based Functional Nanomaterials, Nanodrugs, and Biosensors

About this Research Topic

Beyond genetic reprogramming, nucleic acids with predictability, precise molecular recognition, inherent physiological functions, biocompatibility, and biodegradability have been employed as powerful building blocks in the construction of responsive materials and nanoscale engineering as well biosensors. A variety of nucleic acid-based probes or functional nanomaterials have been developed for potential applications including diagnostics, smart vehicles, controlled drug release systems, tissue engineering, therapeutics, protein production, and the exploration of life evolution.

This Research Topic will focus on engineering nucleic acids as functional nanomaterials to perform in the fields of nanomaterials and nanodrugs, and as biomarkers or biomedical imaging to detect biomolecules in vivo or in vitro. The aim of this Research Topic is also to focus on the application of aptamers and ribozymes or non-coding RNAs (ncRNAs) in cancer diagnosis and therapy research, pharmacological targets.  

We welcome Original Research papers, Reviews, Mini-reviews, Theory or Methods papers. Themes of interest include, but are not limited to:

- The construction of DNA secondary structures (DNA duplex, hairpins, triplexes, i-motif, quadruplexes DNA) 
- Engineering ncRNA (miRNA, circRNA, IncRNA)
- Engineering DNAzymes and ribozymes 
- Genetic reprogramming and protein expression
- Functional nucleic acid-based nano-hydrogels
- Functional DNA origami 
- Nanomaterials self-assembled from branched DNA
- Artificial DNA nanodrugs as drug delivery
- DNA biosensors including fluorophore-DNA interfaces
- DNA conjugated 2D materials
- Artificial DNA-metals complex


Keywords: ncRNA, Cellular functions, Biosensors, Nanomaterials and Nanodrugs, Engineering DNA


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Beyond genetic reprogramming, nucleic acids with predictability, precise molecular recognition, inherent physiological functions, biocompatibility, and biodegradability have been employed as powerful building blocks in the construction of responsive materials and nanoscale engineering as well biosensors. A variety of nucleic acid-based probes or functional nanomaterials have been developed for potential applications including diagnostics, smart vehicles, controlled drug release systems, tissue engineering, therapeutics, protein production, and the exploration of life evolution.

This Research Topic will focus on engineering nucleic acids as functional nanomaterials to perform in the fields of nanomaterials and nanodrugs, and as biomarkers or biomedical imaging to detect biomolecules in vivo or in vitro. The aim of this Research Topic is also to focus on the application of aptamers and ribozymes or non-coding RNAs (ncRNAs) in cancer diagnosis and therapy research, pharmacological targets.  

We welcome Original Research papers, Reviews, Mini-reviews, Theory or Methods papers. Themes of interest include, but are not limited to:

- The construction of DNA secondary structures (DNA duplex, hairpins, triplexes, i-motif, quadruplexes DNA) 
- Engineering ncRNA (miRNA, circRNA, IncRNA)
- Engineering DNAzymes and ribozymes 
- Genetic reprogramming and protein expression
- Functional nucleic acid-based nano-hydrogels
- Functional DNA origami 
- Nanomaterials self-assembled from branched DNA
- Artificial DNA nanodrugs as drug delivery
- DNA biosensors including fluorophore-DNA interfaces
- DNA conjugated 2D materials
- Artificial DNA-metals complex


Keywords: ncRNA, Cellular functions, Biosensors, Nanomaterials and Nanodrugs, Engineering DNA


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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