Research Topic

Molecular and Cell Biology of Shigella

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Our Research Topic intends to provide a comprehensive and updated view of processes involved in the virulence mechanism of the human pathogen Shigella, the causative agent of bacillary dysentery. This Research Topic is intended to present recent and important findings on the main key steps occurring ...

Our Research Topic intends to provide a comprehensive and updated view of processes involved in the virulence mechanism of the human pathogen Shigella, the causative agent of bacillary dysentery. This Research Topic is intended to present recent and important findings on the main key steps occurring during Shigella invasion, i.e the mechanism of entry, the vacuole lysis, the intercellular dissemination and the host cell signaling taking place during these steps. This Topic will provide contributors with the opportunity to focus on specific aspects of recent findings, which have not been developed in other reviews. These include aspects related to i) the structural detail of the type three secretion apparatus; ii) the role of bacterial effectors involved in virulence; iii) the subversion of host cell recycling compartment required for vacuole lysis; iv) newly described bacterial and host cell players during Shigella spreading from cell-to-cell; Shigella control of cell death and survival pathways. We will also review the latest technical advances and the development of molecular tools to study Shigella invasion of host cell, and the response of the latter.
More specifically, this Research Topic will address the following questions on the virulence of Shigella: how is the type three secretion system regulated? What insights into its mechanism can we infer from structural approaches? How and when are the virulence factors required during invasion? How does Shigella utilize the host cell to enhance its invasion, evade the immune response and disseminate intercellularly to promote bacillary dysentery in humans?


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