About this Research Topic
Mitochondria are highly dynamic organelles that participate in ATP generation, calcium homeostasis, oxidative stress response and apoptosis. Thus, maintaining the homeostasis of mitochondria is critical for cellular functions. Indeed mitophagy is a specialized autophagic process that selectively degrades damaged mitochondria under mitochondrial toxicity conditions, playing a crucial role in mitochondrial quality control. An impaired autophagic response is closely related to the pathogenesis of many diseases.
In particular, the myocardium is a highly oxidative metabolic tissue and mitochondria play a central role in maintaining optimal performance of the heart. Accumulation of dysfunctional mitochondria is involved in the pathophysiology of cardiovascular diseases, such as myocardial infarction, cardiomyopathy and heart failure.
This Research Topic aims to describe the most recent advances, together with novel and outstanding findings on mitophagy regulation and its role in cardiovascular disease and how it could represent a possible therapeutic target for drug development and discovery. A particular focus will be on unveiling the molecular components regulating the mitochondrial degradation system, and its impact in the coordination of cellular responses in cardiac homeostasis and stress.
In particular, the myocardium is a highly oxidative metabolic tissue and mitochondria play a central role in maintaining optimal performance of the heart. Accumulation of dysfunctional mitochondria is involved in the pathophysiology of cardiovascular diseases, such as myocardial infarction, cardiomyopathy and heart failure.
This Research Topic aims to describe the most recent advances, together with novel and outstanding findings on mitophagy regulation and its role in cardiovascular disease and how it could represent a possible therapeutic target for drug development and discovery. A particular focus will be on unveiling the molecular components regulating the mitochondrial degradation system, and its impact in the coordination of cellular responses in cardiac homeostasis and stress.
Keywords: therapeutic targets, cardiovascular disease, mitophagy, drug development
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