About this Research Topic
Recently, there has been an increasing body of evidence regarding the role of mitochondria in the pathogenesis of human disease. Mitochondria have been known to play a central role in the regulation of cell death pathways. Having multiple and diverse biological functions such as energy generation, biosynthesis of fatty acids, calcium storage, immune regulation, and cell death pathways makes them a lucrative target for bacterial pathogens. Perturbations in mitochondrial functions can affect the outcome of bacterial infections in terms of the onset and progression of disease. Various bacterial pathogens are known to affect mitochondrial dynamics and function to influence their survival or to evade host immunity. On the other hand, in response to bacterial infection, the host response elicited against infections is largely dependent on mitochondrial functions, placing mitochondria in a strategic position for maintaining homeostasis.
Bacterial pathogens like Mycobacterium tuberculosis, ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), and many other bacteria pose a serious threat and are responsible for millions of deaths worldwide. Emerging resistance to various antibiotics used for the treatment and management of disease makes the situation even more critical. Understanding host-pathogen interaction, especially mitochondrial role and signaling could pave the way for a better understanding of bacterial disease pathogenesis and help guide future therapeutics.
The current research topic aims to encompass molecular mechanisms during host-pathogen interaction in relation to mitochondria and fill the knowledge gap in microbiology to lay the foundation for future treatment and diagnosis.
This comprehensive Research Topic welcomes cutting-edge research on bacterial infection and mitochondrial function. We welcome Original Research Articles, Reviews, Mini-Reviews, Perspectives, and Methods articles on:
• recent advances in mitochondrial biology in bacterial pathogenesis
• the crosstalk between Mycobacterium tuberculosis and mitochondria
• ESKAPE pathogen’s role in modulating mitochondrial functions
• mitochondrial signaling in host-pathogen interaction
• mitochondrial dynamics and infection
• involvement of mitochondria in bacterial infectious disease.
Bacterial pathogens like Mycobacterium tuberculosis, ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), and many other bacteria pose a serious threat and are responsible for millions of deaths worldwide. Emerging resistance to various antibiotics used for the treatment and management of disease makes the situation even more critical. Understanding host-pathogen interaction, especially mitochondrial role and signaling could pave the way for a better understanding of bacterial disease pathogenesis and help guide future therapeutics.
The current research topic aims to encompass molecular mechanisms during host-pathogen interaction in relation to mitochondria and fill the knowledge gap in microbiology to lay the foundation for future treatment and diagnosis.
This comprehensive Research Topic welcomes cutting-edge research on bacterial infection and mitochondrial function. We welcome Original Research Articles, Reviews, Mini-Reviews, Perspectives, and Methods articles on:
• recent advances in mitochondrial biology in bacterial pathogenesis
• the crosstalk between Mycobacterium tuberculosis and mitochondria
• ESKAPE pathogen’s role in modulating mitochondrial functions
• mitochondrial signaling in host-pathogen interaction
• mitochondrial dynamics and infection
• involvement of mitochondria in bacterial infectious disease.
Keywords: host-pathogen interaction, mitochondrial biology, infection, mitochondria, innate immunity, ESKAPE pathogens, mycobacterium tuberculosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
