T lymphocytes exert a vital role in the regulation and function of the immune system. Both effector and regulatory T (Treg) cells cooperate to produce an ideal immune response against invading pathogens. Typically, T cells can discriminate foreign pathogens from our own cells due to immune tolerance. Treg cells are responsible for preserving immunological homeostasis. The occurrence of autoimmune disorders is attributed mainly to disturbances in Treg function, suggesting that immunotherapies targeting Treg cells are a tool for the treatment of autoimmune disorders.
Systemic lupus, a common inflammatory and multisystem autoimmune disease, is associated with immune complex deposition, causing damage to various organs. The disease mainly occurred due to dysfunction of Treg cells. Moreover, rheumatoid arthritis is a chronic autoimmune disorder that frequently affects joints. In rheumatoid arthritis, the frequencies and functions of Treg cells were reduced, causing an imbalance between Treg cells and effector T cells.
This Research Topic aims to illustrate the cellular and molecular mechanisms of lupus and rheumatoid arthritis and emphasize the clinical outcomes, recent advances in diagnostics, and therapeutic strategies targeting lupus and rheumatoid arthritis. Herein, we highlight the inflammatory mechanisms associated with lupus and rheumatoid arthritis as common autoimmune disorders, with a special focus on Treg and the most significant unanswered questions and guidelines for future research on this evolving topic. As a result, this Research Topic aims to offer a new window of possible multidisciplinary strategies based on regulatory immune cells.
We welcome all manuscript types focusing on, but not limited to:
· Cellular and molecular mechanisms of lupus and rheumatoid arthritis.
· Treatment strategies for lupus and rheumatoid arthritis.
· Autoimmune biomarkers involved in lupus and rheumatoid arthritis.
· Recent diagnostic approaches for lupus and rheumatoid arthritis.
· One health approach as a counter-measure against lupus and rheumatoid arthritis.
Keywords:
· Lupus, rheumatoid arthritis, Treg cells, autoimmune biomarkers, immune checkpoints
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
T lymphocytes exert a vital role in the regulation and function of the immune system. Both effector and regulatory T (Treg) cells cooperate to produce an ideal immune response against invading pathogens. Typically, T cells can discriminate foreign pathogens from our own cells due to immune tolerance. Treg cells are responsible for preserving immunological homeostasis. The occurrence of autoimmune disorders is attributed mainly to disturbances in Treg function, suggesting that immunotherapies targeting Treg cells are a tool for the treatment of autoimmune disorders.
Systemic lupus, a common inflammatory and multisystem autoimmune disease, is associated with immune complex deposition, causing damage to various organs. The disease mainly occurred due to dysfunction of Treg cells. Moreover, rheumatoid arthritis is a chronic autoimmune disorder that frequently affects joints. In rheumatoid arthritis, the frequencies and functions of Treg cells were reduced, causing an imbalance between Treg cells and effector T cells.
This Research Topic aims to illustrate the cellular and molecular mechanisms of lupus and rheumatoid arthritis and emphasize the clinical outcomes, recent advances in diagnostics, and therapeutic strategies targeting lupus and rheumatoid arthritis. Herein, we highlight the inflammatory mechanisms associated with lupus and rheumatoid arthritis as common autoimmune disorders, with a special focus on Treg and the most significant unanswered questions and guidelines for future research on this evolving topic. As a result, this Research Topic aims to offer a new window of possible multidisciplinary strategies based on regulatory immune cells.
We welcome all manuscript types focusing on, but not limited to:
· Cellular and molecular mechanisms of lupus and rheumatoid arthritis.
· Treatment strategies for lupus and rheumatoid arthritis.
· Autoimmune biomarkers involved in lupus and rheumatoid arthritis.
· Recent diagnostic approaches for lupus and rheumatoid arthritis.
· One health approach as a counter-measure against lupus and rheumatoid arthritis.
Keywords:
· Lupus, rheumatoid arthritis, Treg cells, autoimmune biomarkers, immune checkpoints
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.