Exploring Endocrine and Nutritional Metabolism's Role in Tumor Development and Progression

The relationship between endocrine disorders and tumors has long been a focal point in medical research, with recent studies highlighting the significant role of nutritional metabolism in this dynamic. The endocrine system, responsible for regulating physiological processes through hormone signaling, is intricately linked to nutritional metabolism, the process by which cells acquire and utilize nutrients. Abnormalities in these systems can lead to tumor development, as evidenced by the upregulation of glutamate dehydrogenase (GDH) in colorectal cancer cells, which induces epithelial-mesenchymal transition to enhance cell proliferation and migration. Additionally, the Vitamin D receptor (VDR) influences energy homeostasis and is associated with obesity-related endocrine diseases. Despite these findings, there remains a gap in understanding the precise mechanisms by which nutritional metabolic abnormalities contribute to tumorigenesis. Addressing this gap could lead to novel therapeutic targets and improved treatment strategies for tumors.

This Research Topic aims to elucidate the intricate relationship between changes in endocrine and nutritional metabolism and tumor development. By exploring why abnormalities in nutritional metabolism may lead to tumors and how they influence tumor progression, the topic seeks to uncover new therapeutic targets, develop innovative drugs, and optimize existing treatments. The ultimate goal is to translate these findings into effective treatment strategies, providing new insights and approaches for the prevention and management of tumors.

To gather further insights into the complex interplay between endocrine nutritional metabolic abnormalities and tumor development, we welcome Original Research, Reviews, Mini-reviews, Methods, Perspectives, and Opinion articles addressing, but not limited to, the following themes:
- Vitamin involvement in tumor development and progression
- Endocrine nutritional metabolic abnormalities between cancer and stromal cells in the tumor microenvironment
- New insights into nutritional metabolic abnormalities in endocrine-related diseases
- The impact of metabolism reprogramming on therapy responsiveness
- Endocrine-related deficiencies associated with the risk of developing endocrine-related diseases and tumors
- Metabolism-targeted treatments and nutrient-based therapies
- The role of diets with different nutrient intakes on the outcomes of patients affected by endocrine-related tumors.