Redox signaling is a burgeoning field within biology and medicine, focusing on the roles of reactive species such as reactive oxygen species, nitric oxide, hydrogen sulfide, and oxidized lipids. These molecules are increasingly recognized for their critical signaling roles in various biological processes, including embryonic development, metabolic pathways, lifespan regulation, and tissue regeneration. Despite significant advancements, the dysregulation of redox homeostasis remains a prevalent issue in numerous diseases, metabolic dysfunctions, and age-related degenerations. Current research has yet to fully elucidate the specific cellular targets of these reactive species and the precise mechanisms by which redox signals are transmitted within cells. Addressing these gaps is crucial for advancing our understanding of redox processes and their implications for health and disease.
This research topic aims to uncover novel roles of reactive species, such as oxygen, nitrogen, and sulfur, in developmental processes, metabolic pathways, and age-related degenerations. It seeks to explore how cells and organisms respond to various reactive species under different conditions and how these species facilitate intercellular communication. A primary objective is to elucidate the mechanisms of redox regulation in cellular processes, with a focus on identifying specific participants involved in redox transmission. By doing so, the research endeavors to create new opportunities for addressing global health and well-being challenges.
To gather further insights into redox control in metabolism, development, and aging, we welcome articles addressing, but not limited to, the following themes:
- Identification of redox-sensitive targets in developmental processes and metabolic dysfunctions.
- Investigation of redox signaling transduction in model organisms, including bacteria, yeast, C. elegans, Drosophila, Arabidopsis, mice, and humans.
- Exploration of reversible oxidation as a novel regulatory posttranslational modification.
- Studies on the physiological significance of redox signaling in aging.
- Integration of redox control mechanisms across different biological systems and conditions.
Keywords: redox signaling, redox regulation, redox metabolism, reactive species, redox modification
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
