High-density lipoprotein (HDL) is well recognized for its cardio-protective effects, yet recent research has revealed the complexity of HDL's role in cardiovascular disease (CVD) beyond traditional cholesterol transport. This Research Topic delves into the nuanced interplay of HDL-related factors influencing cardiovascular health, examining the mechanisms through which HDL impacts CVD progression. The growing body of evidence suggests that HDL subfractions and their corresponding functionalities might offer predictive value for cardiovascular risk, shedding light on metabolic syndrome progression and the potential for targeted therapeutic strategies.
This Research Topic aims to broaden understanding of the diverse roles and mechanisms of HDL in cardiovascular health. It seeks to uncover how changes in HDL levels, subclasses, and functionality over time correlate with cardiovascular events and outcomes, and how these can be harnessed in clinical practice. Additionally, the topic explores the effects of various lipid-lowering medications, such as statins, PCSK9 inhibitors, and fibrates, on HDL metabolism and functionality, providing insights into optimizing treatment approaches for individuals with CVD.
To gather further insights in this rapidly advancing field, we welcome articles addressing, but not limited to, the following themes:
-Characterization and clinical significance of HDL subfractions
-Biomarkers of HDL functionality as predictors of cardiovascular risk
-Longitudinal studies on HDL variability and cardiovascular outcomes
-Impact of lipid-lowering therapies on HDL composition and function
-Innovative therapeutic strategies targeting HDL to improve cardiovascular health
By focusing on these key areas, this Research Topic aims to advance the understanding of HDL's protective mechanisms in CVD, potentially guiding future clinical applications and therapeutic developments.
Keywords: HDL
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
