Organoid and organ-on-a-chip technologies represent a transformative leap in the field of biomedical science. Historically, traditional in vitro methods have been invaluable but inherently limited due to their two-dimensional nature, which fails to capture the complexity of human tissues and organ architecture. As a result, translational applications have been constrained. Recently, breakthroughs in three-dimensional organoids and biomimetic organs-on-a-chip have shown increased fidelity in replicating human tissue environments, enabling enhanced disease modeling and drug delivery research. However, challenges remain, particularly in the precise characterization and standardization of these systems, as well as in understanding the impacts of cellular signaling, electrical activities, and specific microenvironments on tissue organization and function.
This Research Topic aims to consolidate and clarify the current advancements in organoid and organ-on-a-chip methodologies. It focuses on addressing the incomplete knowledge about disease mechanisms, drug responses, and the potential applications in personalized medicine. Personalized medicine leverages individual genetic, environmental, and lifestyle information to design tailored therapeutic strategies. Organoid and organ-on-a-chip platforms can mimic patient-specific tissue responses, serving as powerful tools in disease modeling. They allow for the identification of unique disease pathways, biomarker discovery, and the prediction of patient-specific drug efficacy and toxicity. Furthermore, these technologies hold promise for unraveling the genetic and molecular underpinnings of complex diseases, thus refining the development of individualized treatment plans.
To gather further insights within the domain of organoids and organ-on-a-chip technologies, we invite original research and review articles addressing, but not limited to, the following themes:
• Advances in microfluidic platforms for controlled organoid development • Techniques for measuring and analyzing electrical signals within organoid and organ-on-a-chip systems • Integration of stem-cell-based models, especially induced pluripotent stem cells, for personalized medicine and precision therapeutics • Applications and validations of these technologies in modeling diseases like cancer, neurological, and metabolic disorders • Novel methods for drug screening, efficacy testing, and targeted drug delivery using these advanced models • Utilization of organoid and organ-on-a-chip systems in uncovering novel disease mechanisms and therapeutic targets
By further exploring these innovative systems, we aim to enhance their applicability in both personalized medicine and disease modeling, ultimately translating these findings into practical clinical solutions.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
