Monogenic Inborn Errors of Immunity Associated with Atopy

Inborn errors of immunity (IEI) comprise a group of monogenic disorders resulting from mutations in genes responsible for immune host defence and immunoregulation. Allergic manifestations such as food allergy, atopic dermatitis, and allergic asthma can occur in patients with IEI and might even be the initial presentation, with commonly delayed diagnosis and inappropriate management. Increasing awareness of allergists and pediatricians towards this problem is essential for early recognition of IEI in the context of an allergic phenotype and crucial to ensuring prompt diagnosis and appropriate personalized treatment with the provision of a multidisciplinary approach.

This Research Topic will help better understand the relationship between allergic diseases and IEI, the underlying genetic mutations and pathogenetic mechanisms that can explain this relationship and discuss the red flags that should draw the attention of the allergists to investigate for underlying IEI. It will also help underline the substantial impact of reaching an IEI diagnosis on patient care and management.

Suitable themes for this Research Topic include, but are not limited to:
• Determination of the prevalence of IEI in patients with allergic diseases
• Investigating different types and mutations of IEI that can present with allergic phenotype and also determining the subgroups of IEI that are more likely to present with atopy and should be given priority in diagnosis
• The underlying pathogenetic mechanisms resulting in atopic phenotypes among patients with different types of IEI
• When to suspect and how to investigate for IEI among patients with atopic phenotypes
• Clinical experience in patients with IEI presenting with allergic manifestations and the influence of IEI diagnosis on the management of allergic diseases in those patients and their response to treatment
• The safety and efficacy of the commonly used biological therapies in allergic diseases among patients with IEI with atopic phenotype

All article types accepted by Frontiers in Allergy are welcome.

Keywords: Allergy, Asthma, Eczema, primary immunodeficiency, monogenic atopy, immune dysregulation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.