Given the success of Research Topic The Interplay between Endocrine and Immune Systems in Metabolic Diseases and the rapidly evolving subject area, we are pleased to launch the second volume.
The field of metabolic diseases has garnered significant attention due to its increasing prevalence and the substantial public health burden it imposes. Metabolic diseases, such as obesity, diabetes, hereditary hemochromatosis, and cystic fibrosis, are characterized by metabolic dysregulation across various tissues. Despite extensive research, the pathogenesis of these diseases remains largely elusive, involving a complex interplay of genetic factors and overlapping molecular pathways. Recent studies have highlighted a potential link between metabolic diseases and abnormal immune system function, often manifesting as chronic inflammation. This inflammation is believed to contribute to abnormal metabolism at both general levels and local tissues. Notably, metabolic changes, including those in energy, glucose, and lipid metabolism, have been shown to directly regulate cell differentiation, function, and polarization. However, the precise cellular and molecular mechanisms underlying these interactions remain unclear, presenting a critical gap in our understanding that this Research Topic seeks to address.
This Research Topic aims to explore the intricate interplay between the endocrine and immune systems in the context of metabolic diseases. The primary objectives include investigating the interactions between endocrine and immune cells, understanding how these interactions lead to metabolic changes in immune cells, and examining how these changes affect immune cell function, differentiation, and polarization. Additionally, the topic will delve into how these abnormal immune cells contribute to the pathogenesis of metabolic diseases, with a focus on uncovering the underlying molecular mechanisms. Through this exploration, we aim to provide a deeper understanding of the pathogenesis of metabolic diseases and propose potential therapeutic approaches targeting the endocrine-immune interplay, offering new avenues for treatment.
To gather further insights into the complex interactions between the endocrine and immune systems in metabolic diseases, we welcome articles addressing, but not limited to, the following themes:
- The cellular interplay between endocrine and immune systems.
- The role of endocrine-immune interplay in the metabolic changes of immune cells.
- The link between metabolic changes and the function, differentiation, and polarization of immune cells.
- The role of immune cells with metabolic changes in the pathogenesis of metabolic diseases.
- Potential therapeutic approaches to target the endocrine-immune interplay.
Some of the preferred specific sub-themes include:
- Cellular and molecular mechanisms under the endocrine-immune interplay.
- Immunometabolism.
- Therapeutic strategies/approaches to target the endocrine-immune interplay.
Topic Editors welcome Original Research papers, Reviews, and Mini Reviews.
Keywords: endocrinology, immunology, metabolic diseases, immunoregulation, metabolism
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
