Advancements in Molecular and Cellular Mechanisms of Stem Cells in Tissue Development and Regeneration

The field of stem cell research has garnered significant attention due to its potential to revolutionize our understanding of tissue development and regeneration. Stem cells, with their unique ability to differentiate into various cell types, are central to both developmental and regenerative processes. Despite their promise, several questions remain unanswered, particularly concerning the mechanisms that govern stem cell behavior in these contexts. Recent studies have highlighted the importance of the stem cell niche and its influence on stem cell function, yet the intricacies of these interactions are not fully understood. While significant strides have been made in identifying factors critical for regeneration in highly regenerative organisms, the translation of these findings to less regenerative species, including humans, remains a challenge. There is a pressing need to bridge these knowledge gaps to harness stem cells' full potential in therapeutic applications.

This research topic aims to explore the molecular and cellular mechanisms by which stem cells contribute to tissue development and regeneration. The primary objectives include understanding the role of stem cells in organogenesis, elucidating the cellular and molecular pathways involved in prenatal tissue repair, and investigating the alterations in stem cell function that lead to developmental disorders. Additionally, the research seeks to uncover the limitations of stem cell-mediated regeneration in adult tissues and explore advanced techniques for stem cell manipulation and transplantation.

To gather further insights into the molecular and cellular mechanisms of stem cells in tissue development and regeneration, we welcome articles addressing, but not limited to, the following themes:
- Stem cell functions and mechanisms in tissue and organ development in multicellular organisms.
- Cellular and molecular mechanisms of stem cell populations in prenatal tissue repair and injury.
- Alterations in stem cell function in developmental disorders.
- Stem cell defects affecting various tissue regeneration outcomes in adult animals.
- Advanced techniques in stem cell manipulation and transplantations aimed at correcting developmental defects and improving adult tissue regeneration.


We invite submissions that will make a unique contribution to the field, including primary research articles, review articles, and novel protocols and techniques. Your work has the potential to significantly advance the understanding of the role of stem cells in regeneration and development, and we value your contribution to the scientific community.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Stem cells, Development, Regeneration, Re-programing, Stem cell therapy, Progenitors

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.